Aviation weather for Escuela Mariscal Sucre airport in Maracay area (Venezuela) is “SVBS 302303Z AUTO NIL” : See what it means on https://www.bigorre.org/aero/meteo/svbs/en #maracay #venezuela #escuelamariscalsucreairport #svbs #myc #metar #aviation #aviationweather vl

Aviation weather for Escuela Mariscal Sucre airport in Maracay area (Venezuela) is “SVBS 301103Z AUTO NIL” : See what it means on https://www.bigorre.org/aero/meteo/svbs/en #maracay #venezuela #escuelamariscalsucreairport #svbs #myc #metar #aviation #aviationweather vl

Synthetic Miniproteins Inhibit “Undruggable” Cancer Drug Target

“DuoMYC” binds to the target DNA of the transcription factor MYC, which plays a role in over 50 % of all human cancers

https://www.chemistryviews.org/synthetic-miniproteins-inhibit-undruggable-cancer-drug-target/

#drugdevelopment #anticancer #ebox #myc #transcription factor #chemistry #chemistryviews #chemviews

Researchers identify key regulators underlying #regeneration in #Drosophila.

#RNA_regulator #Brat #Myc

https://phys.org/news/2024-03-key-underlying-regeneration-drosophila.html

«The protein #MYC is part of healthy cell activity, but wheN #cancer cells develop, it goes haywire – going outside of its normal, carefully controlled role and helping cancer to spread. Now, scientists may have found a way to stop this from happening.»

https://www.sciencealert.com/one-protein-helps-75-of-cancers-to-spread-and-we-may-have-a-way-to-stop-it

4-JAN-2024
Scientists tame chaotic protein fueling 75% of cancers
Discovery opens window to more effective treatment

https://www.eurekalert.org/news-releases/1030250 #science #nanoworld #IntrinsicallyDisorderedProteins #myc #cancer #proteins #ProteinFolding

How #plants respond to environmental #threats with the proper defense.

#signalling #jasmonate #JAZ #MYC #immunity

https://phys.org/news/2023-09-environmental-threats-proper-defense.html

"Dark & Disordered", a tetraptych in the Dark Proteome series. #darkProteome #MYC

#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer

Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling

https://www.embopress.org/doi/10.15252/embj.2022112614

Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Some new cancer news for y'all.

The MYC family of regulatory genes help control cell growth and proliferation and are known to be constantly on in cancerous cells.

Now, researchers at the University of Würzburg have found that these MYC proteins form into spheres under stressful conditions, thereby causing the proliferation.

Destroying them would also likely kill the cancer cell they belong to.

#Cancer #Biology #Medicine #MYC #sciencemastodon #scicomm

https://www.nature.com/articles/s41586-022-05469-4

#MYC #genes and their #proteins play a central role in the emergence and development of almost all #cancers. They drive the uncontrolled growth and altered metabolism of tumor cells. And they help tumors hide from the #immune system.
#Biology #Pharmaceutical #sflorg
https://www.sflorg.com/2022/11/bio11252202.html

Hello everyone, I'm a scientist who now writes about cool science in the oncology arena. Currently interested in #TPD #KRAS #MYC and other emerging areas of interest.

Happy I got to spend this evening celebrating some of my favorite people from MYC, AFSC Indy, and JVP! Grateful for all the work you do to make this city a better place for the most marginalized! #afscindiana #myc #jvp #selfie #friends
https://www.instagram.com/p/BufdEsbFbsD/