Our research is now supported by a 2024 Simons Foundation Autism Research Initiative (SFARI) Pilot Award, co-funded by the Nancy Lurie Marks Family Foundation (NLMFF). I am grateful to both SFARI and NLMFF for investing in high-risk, high-reward science to advance understanding of autism spectrum disorders (ASD) and neurodevelopmental disorders.

The project will explore how mutations in chromatin regulators ASH1L and SETBP1 impair their crucial role in guiding the development of GABAergic neurons—key cells maintaining the brain’s balance between excitation and inhibition. Disruptions in this process are strongly linked to ASD, but the molecular pathways remain poorly understood.

By integrating genomic, proteomic, and functional approaches, we aim to reveal how these enzymes regulate gene activity during inhibitory neuron development and how their dysfunction contributes to ASD.

Official announcements:
SFARI: https://www.sfari.org/2025/04/08/announcing-the-recipients-of-the-2024-pilot-and-pilot-progression-awards/
NLMFF: https://www.nlmfoundation.org/grant/epigenetic-regulators-ash1l-and-setbp1-in-gabaergic-neuron-development-and-asd/

#newsmayerlab #SFARI #NLMFF #AutismResearch #Neurodevelopment #Epigenetics #GABA #Genomics #Chromatin #Neuroscience

Just returned from the Paris-Munich #Epigenetics Symposium—thank you to the organizers for the kind invitation and the opportunity to present our lab’s work. Grateful to be part of such a thoughtful and inspiring community. #newsmayerlab

Our lab at the MPI-BI is now using #Matrix for team communication. A decentralized and secure solution that avoids tech company monopolies and supports open, flexible collaboration. #NewsMayerlab

Our lab at the Max Planck Institute for Biological Intelligence (Campus Martinsried) is hiring a Student Assistant (HiWi). The position can be filled as soon as possible and is open only to students enrolled at a university in Munich. All details here:All details here: https://keeper.mpdl.mpg.de/f/92efd20d4e5948fa955e/

#Hiring #LabTechnician #BiologyJobs #Neuroscience #MolecularBiology #CellBiology #ResearchJobs #ScienceJobs #AcademicJobs #NewsMayerlab #MPI

Our lab at the Max Planck Institute for Biological Intelligence (Campus Martinsried) is hiring a lab technician. The position can be filled as soon as possible. All details here: https://keeper.mpdl.mpg.de/f/047f7d13e1a54a26b1ae/

#Hiring #LabTechnician #BiologyJobs #Neuroscience #MolecularBiology #CellBiology #ResearchJobs #ScienceJobs #AcademicJobs #NewsMayerlab #MPI

🎓📢 The Mayer Lab at the Max Planck Institute for Biological Intelligence in Munich seeks a Master's student, Erasmus+, or HiWi for research on GABAergic neuron fate in brain organoids.

🔬 Contribute to cutting-edge research using gene perturbation techniques in brain organoids.

📅 Start: February 2025 or later. Preference for candidates committing to a year or longer.

📩 Details: https://keeper.mpdl.mpg.de/f/f454be68cc7c49649b4b/

🌐 Learn more: MayerLab.net

#Neurogenomics #ResearchOpportunity #ScienceJobs #newsmayerlab

We’re hiring!

Join our lab at the Max Planck Institute for Biological Intelligence in Munich. Open positions for Postdocs, PhD students, Master’s students, and Technicians to work on wet lab molecular biology projects exploring gene regulation and neuronal diversity.

More information here: https://mayerlab.net/join-us/

#Neuroscience #MolecularBiology #AcademicJobs #WetLab #GeneRegulation #PostdocJobs #PhDPositions #NewsMayerLab

Pleased to share a review I contributed to, now published in Nature Neuroscience: Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system.

The article highlights how lineage tracing sheds light on cell fate decisions and molecular mechanisms in development and disease. Read here: https://doi.org/10.1038/s41593-024-01827-9

#SingleCell #Neuroscience #Genomics #newsmayerlab

Thank you to the organizers of the ‘Developmental Specification of Complex Behaviors’ conference at #JaneliaResearch for the opportunity to present our work. It was a fantastic meeting, and we had great discussions on the latest insights into developmental neurobiology! #NewsMayerlab

I had a great time traveling to the US this week to present our research at the #CSHL (Cold Spring Harbor Laboratory) neuro seminar series. Thanks to my hosts for a great visit. #NewsMayerlab

Taking some time to enjoy the #Oktoberfest with the team! A great chance to unwind and celebrate together. Prost to good company, and great teamwork! 🍻 #LabLife #NewsMayerlab

New study "Multiple parallel cell lineages in the developing mammalian cerebral cortex" led by Lucia Del-Valle-Anton and the @Borrell_Lab (Alicante) is published. Great collaboration with the labs of Juan Antonio Moreno-Bravo (Alicante) and Magdalena Götz (Munich). Congrats to our lab members Florian Neuhaus, @Elena_dvoretskova, Yigit Babal, Chao Feng for their contribution! Link: https://www.science.org/doi/10.1126/sciadv.adn9998 @MPIforBI #NewsMayerlab"

Excited to announce that our study "Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development" is now online in Nature Neuroscience https://www.nature.com/articles/s41593-024-01611-9 Big thanks to the Winkelmann (#Helmholz @tu_muenchen & Torres (#CNIC_CARDIO) labs for the collaboration! #NewsMayerlab. See the thread to find out more: 1/7

Unsere aktuellste Arbeit wurde auf der Website des Max-Planck-Instituts für Biologische Intelligenz präsentiert! Schauen Sie sich den Artikel an, um mehr zu erfahren: https://www.bi.mpg.de/news/2024-03-mayer/de #Wissenschaft #Neurowissenschaften #Forschung #NewsMayerlab

Our most recent work has been featured on the MPI Biological Intelligence website! Check out the article to learn more: https://www.bi.mpg.de/news/2024-03-mayer #Science #Neuroscience #Research #NewsMayerlab

How does the competence of GABAergic progenitors change in time? Well, it depends on whether you're looking at maturation or differentiation! Check out our new preprint on #BioRxiv: https://doi.org/10.1101/2024.03.18.585524
Big shoutout to the amazing contributors, Yana, Ann, Flo, Ilaria and our collaborators Diana Rodrigues and Mike Myoga! #NewsMayerlab

Explore the behind-the-scenes video showcasing Yana and Ann in our lab! Gain exciting insights into our work at MPI for Biological Intelligence. Watch the video here: https://www.bi.mpg.de/2658079/behind-the-scenes-neurodevelopment #LabLife #MPIforBI #NewsMayerlab

I had the pleasure of hosting @hjerlingleffler at the #MPI-BI seminar series. His insights into the aetiology of schizophrenia are truly fascinating. https://x.com/HjerlingLeffler/status/1732071819371336087?s=20 #SchizophreniaResearch #JensHjerlingLeffler
#NewsMayerlab

Tomorrow, 27.10, I'll be presenting our lab's research on understanding the development of cell lineages in space and time at the CiM-IMPRS Graduate School Meeting in Münster. Looking forward to meeting talented students and researchers from CiM-IMPRS! #IMPRS #NewsMayerlab

Thrilled to be at the Karolinska Institute in Stockholm for the Developing Brains 10th Anniversary Conference! Looking forward to presenting our lab's research on #lineage and #Meis2 this Friday. Excited to be part of this incredible event. Great discussions ahead! #DevelopingBrains #NewsMayerlab