A team led by Yong-Qiang Tu (Lanzhou University, #China) has developed a highly enantioselective approach to synthesize α-ethynylated 3-substituted oxindoles using a hypervalent iodine alkynyl donor and a triazolium bromide catalyst. This method delivers excellent yields and enantioselectivity, providing key intermediates for alkaloid synthesis — demonstrated in their recent publication in Angewandte Chemie.

https://onlinelibrary.wiley.com/doi/10.1002/anie.202506065

#chemistry #orgchem #science @chemistry

When you think of a reaction between an acid and an alcohol, you think of an ester as the product. MacMillan and co-workers from Princeton have now described a different pathway: Selective decarbonylative C-C coupling via a metal-catalyzed photoredox reaction. Read more about this in JACS:

https://pubs.acs.org/doi/10.1021/jacs.4c15827

#chemistry #JACS #OrgChem #Science

If you are curious about the work, you can check it in the following link 🤓 : https://doi.org/10.1002/anie.202407813

#chemistry #OrgChem #Catalysis #CompChem #science #research

Radical Fluorosulfonylation of Allyl Bromides:
Catalyst-free protocol under electroreductive conditions
https://www.chemistryviews.org/radical-fluorosulfonylation-of-allyl-bromides/

#orgchem #fluorosulfonylation #chemistry #chemistryviews #chemviews

Site-Selective C–H Functionalization Used to Prepare Atropisomers:
Organic photoredox catalysis provides a general approach to the coupling of biaryls with a range of nucleophiles
https://www.chemistryviews.org/site-selective-c-h-functionalization-used-to-prepare-atropisomers/

#orgchem #biaryls #organocatalysis #chemistry #chemistryviews #chemviews

Enantioselective Heteroarylalkylation Combines Photoredox and Chromium Catalysis:
Radical-polar crossover three-component transformation for the functionalization of 1,3-dienes
https://www.chemistryviews.org/enantioselective-heteroarylalkylation-combines-photoredox-and-chromium-catalysis/

#orgchem #dualcatalysis #chemistry #chemistryviews #chemviews

#RobSelects paper of the week #angew_chem: Generation and characterization of a triphenylphosphine-stabilized monovalent carbon atom with a triplet ground state. #orgchem https://doi.org/10.1002/anie.202424166

Rh(III)-Catalyzed Formal Cycloaddition Provides a Path to Furanones:
Formal [3+2] cycloaddition reaction between cyclopropenones and aldehydes
https://www.chemistryviews.org/rhiii-catalyzed-formal-cycloaddition-provides-a-path-to-furanones/

#orgchem #rhodiumcatalysis #chemistry #chemistryviews #chemviews

Luo et al. from Tsinghua University (#China) report in #JACS a novel method to create enantioenriched α-amino aldehydes using a chiral amine catalyst and iridium photocatalysis. Through this strategy α-amino aldehydes with up to 93% ee could be synthesised and subsequently stabilised via analogues formation (e.g. through Wittig reaction).

https://me.organicchemistry.eu/post/deracemization-aldehyde-jacs-2025/

#Chemistry #Research #Science #OrgChem

Renewable Ethanol and Methanol Used for the Synthesis of 1,5-Diketones:
Nickel-catalyzed coupling of alcohols with ketones also allows for a one-pot aminomethylation
https://www.chemistryviews.org/renewable-ethanol-and-methanol-used-for-the-synthesis-of-15-diketones/

#orgchem #diketones #sustainability #chemistry #chemistryviews #chemviews

Joseph Tuccinardi and John Wood from Baylor University (#USA), introduced a novel strategy to efficiently synthesize the core scaffold of aleutianamine. Their study involved a vinylogous Mukaiyama-Michael reaction cascade using two previously unknown coupling partners. Published in #JACS

https://me.organicchemistry.eu/post/aleutianamine-jacs-2025/

#orgchem #chemistry #totalsynthesis #science

Intense weekend working into this year's Merk #CompoundChallenge. Did we design the best route? Idk, but we sure had lots of laughs.

#OrganicChemistry #OrgChem #Synthesis #Chemistry #Challenge #Science

👩‍🔬🧑‍🔬: Pol Martínez-Balart, Eva Rivera-Chao, Akshay Nair, José L. Nova-Fernández, Saul Alberca, and me.

📷: Pol

Novel method to prepare complex thioxanthones from relatively simple and accessible precursors

https://www.chemistryviews.org/faster-cheaper-smarter-thioxanthone-synthesis/

#chemistry #chemistryviews #chemviews #organicchemistry #orgchem #thioxanthones

Solvent-Controlled, Silver-Catalyzed Cross-Coupling:
Reaction of cyclic aldimines and α-imino-oxy acids gives either nitriles with a cyclic imine or ring-opened oxonitriles
https://www.chemistryviews.org/solvent-controlled-silver-catalyzed-cross-coupling/

#orgchem #chemistry #chemistryviews #chemviews

Nickel-Catalyzed Electrochemical Sulfuration of Alkyl Alcohols:
Thiolation using pyridyl thioesters with a broad substrate scope
https://www.chemistryviews.org/nickel-catalyzed-electrochemical-sulfuration-of-alkyl-alcohols/

#orgchem #electrochemicalsynthesis #chemistry #chemistryviews #chemviews

Electrochemical Cyclopropanation of Unactivated Alkenes:
Organo-mediated electrooxidative cyclopropanation using methylene compounds
https://www.chemistryviews.org/electrochemical-cyclopropanation-of-unactivated-alkenes/

#orgchem #cyclopropanation #chemistry #chemistryviews #chemviews

Annulation of (Trifluoromethyl)alkenes and Thioureas:
Chemoselective defluorinative [3+3] annulation gives dihydropyrimidine derivatives
https://www.chemistryviews.org/annulation-of-trifluoromethylalkenes-and-thioureas/

#orgchem #pyrimidines #chemistry #chemistryviews #chemviews

Solvent-Directed Regioselective Cascade Reaction of Diazo Compounds:
Green, efficient, and regioselective synthesis of pyrazoles
https://www.chemistryviews.org/solvent-directed-regioselective-cascade-reaction-of-diazo-compounds/

#orgchem #pyrazoles #chemistry #chemistryviews #chemviews

Cascade Synthesis of Indole-Fused Benzodiazepines:
Photocatalyzed reaction of α-acetoxy aryl ketones with o-indoloanilines
https://www.chemistryviews.org/cascade-synthesis-of-indole-fused-benzodiazepines/

#photocatalysis #orgchem #synthesis #chemistry #chemistryviews #chemviews

Multicomponent Synthesis Combines Spirooxindoles and Dihydropyridines
Catalyst- and solvent-free, microwave-assisted reaction of isatins, β-ketophosphonates, and primary amines
https://www.chemistryviews.org/multicomponent-synthesis-combines-spirooxindoles-and-dihydropyridines/

#orgchem #microwaveassistedsynthesis #chemistry #chemistryviews #chemviews