I have in the past used #lmde6 and found it 'mostly' okay. My main perceived issues were a general lack of performance on my main PC compared to other DEs, and that #Nemo file manager can be fiddly at times, especially with lots of files, or forgetting custom column widths.
Ultimately, I felt that #lmde didn't bring much to the party for me that I achieve personally with pure #debian, so I stuck with that.
For the last 10+ years, I've used #debian #stable with the #xfce desktop. It has been fine up to and including #bookworm
But I'm seeing #trixie as a step change in a few ways, due to the changes in the industry over the last 2 years. So things like theme conformity across QT and GTK apps are harder as #plasma6 has dropped certain things and isn't feature matched to #plasma5 yet. Plus, a couple of apps and libraries I use haven't made it into #trixie
I have to move on at some point from #bookworm, for security/patch reasons. Just not sure what.