Lmst

Interesting long Covid research study recruiting in Victoria, Australia

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Research Opportunity

Do you live with long COVID and experience fatigue, brain fog, sleep problems, depression or anxiety?

Researchers at Deakin University are testing whether gut-based therapy (faecal microbiome transplantation, FMT) could improve outcomes for people with long COVID.

What’s involved:

5 visits at University Hospital Geelong
3 FMT or placebo enemas
Blood, urine & stool samples
Garmin watch to track activity, sleep & heart rate
Online questionnaires you can complete at home
Parking costs covered

Eligibility: Adults 18–65 with a long COVID diagnosis and moderate to severe symptoms.

Interested? Learn more by contacting the GLOW team at CTUClinicalTrialsUnit@barwonhealth.org.au | (03) 4215 3078

Co-creating a social science research agenda for Long Covid

https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1654488/full

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Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Co-creating a social science research agenda for Long Covid — Cousins et al.
"existing research points to patient experiences, public health impacts, a lack of standardized diagnostic and treatment protocols and pathways and the need for patient involvement as key areas of concern. What is not as clear is the extent to which these priorities are mirrored in the concerns expressed by those researching and living with Long Covid. Our agenda-setting exercise aims to address this gap."

News Release 4-Dec-2025

To treat #longCOVID, we must learn from historical chronic illnesses, medical researchers say

https://www.eurekalert.org/news-releases/1107346

Lots of discussion of ME/CFS in full paper
"The lingering shadow of epidemics: post-acute sequelae across history"
https://www.cell.com/trends/immunology/fulltext/S1471-4906(25)00267-4

#PAIS @mecfs
#MyalgicEncephalomyelitis #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID

News Release 4-Dec-2025
To treat long COVID, we must learn from historical chronic illnesses, medical researchers say
Peer-Reviewed Publication
Cell Press

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1918 Influenza victims crowded into an emergency hospital
image:

Influenza victims crowded into an emergency hospital near Fort Riley, Kansas in 1918.

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Credit: AP Photo National Museum of Health

In a paper publishing in the Cell Press journal Trends in Immunology on December 4, scientists and doctors highlight the importance of studying long COVID in the context of other post-acute infection syndromes or chronic illnesses. By analyzing historical accounts of other epidemics, they say, researchers can gain important perspective on the profound effects of these chronic illnesses—with the goal of informing more effective interventions for treating them.

“Post-acute infection syndromes are a long-overlooked but important area of medicine, and long COVID represents a contemporary manifestation of a phenomenon that’s been described for over a century,” says co-author Christine Miller of Yale School of Medicine.

SARS-CoV-2 Spike Protein Amyloid Fibrils Impair Fibrin Formation and Fibrinolysis

https://pubs.acs.org/doi/full/10.1021/acs.biochem.5c00550

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

SARS-CoV-2 Spike Protein Amyloid Fibrils Impair Fibrin Formation and Fibrinolysis — Henrik Westman et al.
"Despite the limitations of the experimental setup with synthetic fibrils, our data do suggest that some, but not all, Spike-derived amyloid fibrils impacted fibrin folding and assembly and thereby cause impaired plasmin-mediated fibrinolysis."

From Austria:

Postural orthostatic tachycardia syndrome is the most frequent cardiovascular autonomic disorder following COVID-19 infection or vaccination

https://link.springer.com/article/10.1007/s00415-025-13518-x

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#POTS @pots @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Postural orthostatic tachycardia syndrome is the most frequent cardiovascular autonomic disorder following COVID-19 infection or vaccination — Leys et al.
"Here, we aimed to investigate the type and frequency of newly diagnosed and exacerbated CAD following COVID-19 infection or vaccination in a large case series referred to the Innsbruck Dysautonomia Center."

From Germany

Post-COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization

https://onlinelibrary.wiley.com/doi/10.1002/acn3.70260

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

Post-COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization — Tim J. Hartung et al.
"MRI and neuropsychological testing were performed at 3 months after discharge." "Higher acute COVID-19 severity was associated with reduced cortical thickness, particularly in the olfactory system." "reduced cortical thickness of the temporal poles and the anterior and posterior cingulate gyrus was associated with more severe post-acute fatigue."

From Australia:

Persistent lung & vascular inflammation in mild to moderate COVID-19 survivors detected by ¹⁸F-FDG PET/CT: A quantitative imaging study with implications for cardiovascular risk

https://link.springer.com/article/10.1007/s00259-025-07656-7

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver
@novid #novid

Persistent lung and vascular inflammation in mild to moderate COVID-19 survivors detected by ¹⁸F-FDG PET/CT: A quantitative imaging study with implications for cardiovascular risk — Verma et al.
"this new analysis demonstrates strong positive correlations between lung and vascular inflammation, suggesting that the ongoing lung inflammatory response may reflect broader systemic inflammatory activity and could represent a potential mechanism underlying the increased CV risk reported post-COVID."

From Belgium:

"These data demonstrate that IgGs from long COVID patients bind to peripheral sensory neurons and induce pain-related symptoms in mice."

https://www.biorxiv.org/content/10.1101/2025.11.20.689423v1

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice — Mignolet et al.
"These data demonstrate that IgGs from long COVID patients bind to peripheral sensory neurons and induce pain-related symptoms in mice."

Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome

https://www.researchsquare.com/article/rs-7989936/v1

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Autoantibodies mediate pain and sensory dysfunction in post-COVID syndrome — Stuart Bevan et al.
"Here we demonstrate that PCS patients with widespread pain share hyperalgesic sensory phenotypes and spontaneous activity in peripheral nociceptive fibres. Importantly, antibodies from these patients are sufficient to induce painful hypersensitivities and small-fibre neuropathy when administered to mice."

From Italy

Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation

https://biosignaling.biomedcentral.com/articles/10.1186/s12964-025-02502-7

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Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers

Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation — Dalle Carbonare et al.
"Our study demonstrates that LC-EVs carry a distinct molecular signature capable of inducing significant cellular alterations […] enriched in markers of platelet activation and contribute to a pro-thrombotic environment" "Upon entering target cells, LC-EVs promote the expression of RUNX2 and activate stress-related pathways involving p53, p21, and Sestrins, indicating a response to cellular stress […] showing impaired mitochondrial adaptability under metabolic strain, potentially explaining fatigue and exercise intolerance in LC patients."

From South Korea:

Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19

https://www.nature.com/articles/s41467-025-65597-z

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19 — Seo et al.
"The convergence of structural MRI ﬁndings and proteomic alterations in the Cog-PASC group provides insight into potential pathophysiologic mechanisms. Cortical thinning, particularly in the cingulate and insular cortices, may be linked to the observed downregulation of synaptic regulatory proteins, reﬂecting impaired synaptic maintenance and neuronal connectivity."

To Ground Research in the Lived Experience of Patients and Caregivers, Give Us a Voice! by Jeffrey Lubell

https://www.annfammed.org/content/23/6/570

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@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #hEDS @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers
#chronicillness

To Ground Research in the Lived Experience of Patients and Caregivers, Give Us a Voice! — Jeffrey Lubell
"In this essay, I share my thoughts on why patient and caregiver observations and hypotheses are important and how the medical research field might tap into them to make faster progress toward effective treatments for complex medical conditions."

Comprehensive Assessment of Autonomic Nervous System Profiles in Postural Orthostatic Tachycardia Syndrome Among Syncope, Chronic Fatigue, and Post-COVID-19 Patients

https://www.mdpi.com/2075-4418/15/22/2824

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers
#POTS #POTS @pots @mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME

Comprehensive Assessment of Autonomic Nervous System Profiles in Postural Orthostatic Tachycardia Syndrome Among Syncope, Chronic Fatigue, and Post-COVID-19 Patients — Milovanovic et al.
"in CFS patients with POTS (both insidious onset and post-COVID-19), CART findings demonstrated a higher prevalence of definite parasympathetic dysfunction. Together with frequent extreme blood pressure variations during HUTT, these findings indicate that in CFS, POTS is predominantly related to parasympathetic dysfunction, accompanied by inadequate short-term baroreceptor control of blood pressure."

From Stanford (CA, USA):

Can Low Cortisol Predict Long COVID? A Controversial Issue

https://www.mdpi.com/2227-9059/13/11/2636

"Overall, 62.8% of patients had cortisol within the reference range, 36.0% had elevated levels, and only 1.2% (n = 1) had a low value."

#LongCovid #PASC #PostCovid #PostCovid19 @longcovid

From NCNED in Australia:

Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study

Free fulltext:
https://www.sciencedirect.com/science/article/pii/S2666354625002005

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

Abstract
Background
Diverse neurological symptoms are experienced by long COVID and COVID-19 recovered individuals. However, the long-term effects of SARS-CoV-2 in the brain of both groups are underexplored. This study aimed to investigate changes in tissue microstructural and brain neurochemical levels in long COVID and recovered COVID-19 patients compared to healthy controls.
Methods
We recruited 47 participants (long COVID = 19, COVID-recovered healthy controls = 12, and healthy controls without COVID-19 infection = 16) who underwent 3T MRI scans. We acquired T1 and T2 weighted images to assess myelin signal, diffusion weighted images to assess tissue microstructure, and magnetic resonance spectroscopy data to estimate brain neurochemical levels.
Findings
Our multimodal MRI study showed altered T1w/T2w signal between long COVID vs COVID-recovered-healthy controls, long COVID vs healthy controls, and COVID-recovered-healthy controls vs healthy controls. Furthermore, T1w/T2w signal intensity was significantly correlated with physical and cognitive function. Diffusion weighted imaging also showed altered tissue microstructure in these three group comparisons. However, brain neurochemicals were only significantly different between long COVID vs COVID-recovered-healthy controls.

From Belgium:

Improved functional exercise capacity after primary care pulmonary rehabilitation in patients with long COVID (PuRe-COVID)

https://bmjopenrespres.bmj.com/content/12/1/e003653

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers

Improved functional exercise capacity after primary care pulmonary rehabilitation in patients with long COVID (PuRe-COVID): a pragmatic randomised controlled trial — Tess Volckaerts et al.
"This pragmatic, patient-tailored intervention attempted to take PEM into account by informing the physiotherapist about PEM and implementing a five-phase training programme, despite the absence of established guidelines." "Individuals with a high symptom burden or experiencing PEM likely chose not to participate due to concerns about the intensive nature of the programme."

From the UK: CLoCK study

Fatigue in children and young people up to 24 months after infection with SARS-CoV-2

https://www.nature.com/articles/s41598-025-24868-x

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid
#LongCovidKids #LCKids #PASC

Fatigue in children and young people up to 24 months after infection with SARS-CoV-2 — Richards-Belle et al.
"We found limited evidence to suggest that fatigue varied by ethnicity or deprivation" "Additionally, the rate of change in CFQ scores over time was faster in females (with fatigue worsening over time), compared to males (where scores were relatively constant)."

Long-Term Changes in Health-Related Quality of Life and Economic Burden After a SARS-CoV-2 Infection: Analysis of the Long COVID Prospective Cohort Study in Nairobi

https://www.valuehealthregionalissues.com/article/S2212-1099%2825%2900471-6/abstract

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

Long-Term Changes in Health-Related Quality of Life and Economic Burden After a SARS-CoV-2 Infection: Analysis of the Long COVID Prospective Cohort Study in Nairobi — Ângela Jornada Ben et al.
"HRQoL is reduced up to 15 months after a SARS-CoV-2 infection compared with the period before COVID-19 and suggest an inequality gap as participants with better health and socioeconomic status are less likely to experience catastrophic expenditures and costs." "Given the convenience sample and observational design, further research is needed to fully assess the health and economic burden of Long COVID at a national level in Kenya."

The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspective

https://elifesciences.org/articles/106308

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

The role of co-infection in the pathogenesis of acute SARS-CoV-2 infection and development of post-acute sequelae: A perspective — Timothy J Henrich et al.
"we briefly review current evidence on the role of SARS-CoV-2 persistence in tissues as a driver of PASC. In the following sections, we discuss how, in the presence or absence of persistent SARS-CoV-2, other microorganisms may favor the development of PASC or exacerbate its severity."

"We demonstrate significant symptom burden in our LC cohort, with LC associated with mitochondrial [dysfunction] in CD56 bright NK cells and CD4+ lymphocytes, as well as blunted IFN-γ responses to LPS stimulation."

https://dx.doi.org/10.1093/ofid/ofaf447

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@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

#postcovid19

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