Lmst

#progenitorcells

What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @PLOSBiology https://plos.io/3SUN4we

Left: Coronal brain sections of control (top), heterozygous (middle) and knockout (bottom) mice at E13.5 were stained with antibodies recognizing BrdU and Ki67. Pregnant mothers received a BrdU pulse 24 h before embryo collection. Representative cortical regions were shown. Scale bar, 50 μm. Right: A model in which the m5C reader protein Ybx1 regulates the stability of transcripts of key cell cycle regulatory proteins, and its loss leads to impaired proliferation and differentiation in cortical progenitor cells. Image credit: Jian Zhang

Andrew M. Lewis, Jr & Gladys S. Lewis on #PLOSONE December 7, 2023

GLI1+ perivascular, renal, progenitor cells: The likely source of spontaneous #neoplasia that created the AGMK1-9T7 cell line

https://dx.plos.org/10.1371/journal.pone.0293406

#GLI1 #progenitorcells #biomarker #oncology #tumorigenicity #cancercells

Andrew M. Lewis, Jr & Gladys S. Lewis on #PLOSONE 7 December 2023

GLI1+ perivascular, renal, progenitor cells: The likely source of spontaneous #neoplasia that created the AGMK1-9T7 cell line

https://dx.plos.org/10.1371/journal.pone.0293406

#GLI1 #progenitorcells #biomarker #oncology #tumorigenicity #cancercells

screen capture of the headline from the online peer reviewed journal PLOS ONE of a paper published 7 December 23.12.07 by Andrew M. Lewis, Jr, Gladys S. Lewis et al - GLI1+ perivascular, renal, progenitor cells - The likely source of spontaneous neoplasia that created the AGMK1-9T7 cell line

Last session of the conference! Continuing theme of "Cell identity in situ"

Parker Côté, DFCI
in Li Lab
https://ki.mit.edu/people/clinical-investigators-research-fellows/hojun-li

The #transcriptional dynamics of human #hematopoiesis at #SingleCell resolution

do #StemCells and #ProgenitorCells in #hematopoietic system (#HSPC) change with age?

HSPCs exist on a continuum of cell types

They identified #GeneExpression programs active in uncommitted cells, looking across human development (fetal to aged)

https://www.biorxiv.org/content/10.1101/2021.08.25.457678v1

#CSSingleCells23

Referenced link: https://medicalxpress.com/news/2023-06-strategy-cardiac-stem-cellderived-progenitor.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-06-strategy-cardiac-stem-cellderived-progenitor.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1666094279008333824#m

RT by @physorg_com: A novel strategy for cardiac repair using stem cell–derived #progenitorcells and cell-seeding matrix patches https://linkinghub.elsevier.com/retrieve/pii/S2452199X23001676 https://medicalxpress.com/news/2023-06-strategy-cardiac-stem-cellderived-progenitor.html

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