🧩 What happens when we put AlphaFold2’s predictions to the ultimate test—across species and structure types?

🔗 Comprehensive assessment of AlphaFold’s predictions of secondary structure and solvent accessibility at the amino acid-level in eukaryotic, bacterial and archaeal proteins. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.047

📚 CSBJ: https://www.csbj.org/

#AlphaFold #Bioinformatics #StructuralBiology #AlphaFold2 #ProteinStructure #ProteinPrediction #AI

Nice study from @teresa_omeara & @maom in @biorxivpreprint

They used protein prediction to explore the poorly annotated Candida auris genome, and then used protein design to replace endogenous proteins with de novo designed ones.

https://www.biorxiv.org/content/10.1101/2025.05.14.654010v1

#StructuralBiology #AlphaFold2 #proteinPrediction

🔬 Exciting showdown alert! 🌟 Dive into the world of protein structure prediction with #RosettaFold All Atom vs. #AlphaFold - two powerhouses revolutionizing the field. 🧬
https://www.eliza-ng.me/post/sidentifiedfrom_4/
#ProteinPrediction #Bioinformatics #BlogPost

@cmdcolin

I use Alphafold (actually colabfold) and am happy to answer questions, but I'm just a user. There are people with more expertise than me here.

Hashtags might find the right people

#StructurePrediction #alphafold #alphafold2 #colabfold #ProteinStructure #StructuralBiology #ProteinPrediction #protein #bioinformatics

Note in point.

What does it mean when only your rank 1 model suggests an interaction between two proteins with alphafold multimer? Is this garbage?

#AlphaFoldMultimer
#AlphaFold
#AlphaFold2
#ProteinPrediction
#StructurePredictions
#ProteinPredictionHelp

Clearly, there is still much to learn about this corner of the dark genome defined by HEATR5 proteins and their co-factors.

#Biorxiv #Preprint #MembraneTraffic #DarkGenome #DarkProteome #RareDisease #AlphaFold #AlphaFold2 #ProteinPrediction #Golgi #Clathrin #CellBiology #biochemistry #Bioscience