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Tom Kindlontomkindlon@disabled.social
2025-12-20

#SARSCoV2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin

dx.plos.org/10.1371/journal.po

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

SARS-CoV-2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin — Hye-Kyung Lee et al. Rodent study. "S1 treatment led to a marked decrease in the expression of GRIN2A, JPH3, SHANK1, and GRIA2, whereas concurrent metformin treatment restored these levels to control values, suggesting a protective effect against S1-induced synaptic alterations."
Tom Kindlontomkindlon@disabled.social
2025-12-19

From the US:

Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques

researchsquare.com/article/rs-

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques — Tomas R Wiche Salinas et al. "the measurable neurocognitive changes were associated with systemic and nervous system perturbations, indicating a link between infection-induced inflammation and long-term neurological and behavioral outcomes."
Tom Kindlontomkindlon@disabled.social
2025-12-19

From the US

Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19

link.springer.com/article/10.1

Screenshot from Science for ME weekly update

#TeamClots @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19 — Whitcomb et al. "Among patients with active PASC, a distinct proteomic profile emerged which was characterized by persistent elevation of inflammatory markers and tissue remodeling proteins irrespective of initial disease severity. Pathway enrichment analyses identified neutrophil degranulation, platelet activation, and extracellular matrix remodeling as central processes, suggesting that unresolved inflammation and chronic vascular damage may also underlie the development of long-term sequelae."
Tom Kindlontomkindlon@disabled.social
2025-12-19

Omics-based computational approaches for biomarker identification, prediction, and treatment of #LongCOVID

tandfonline.com/doi/abs/10.108

"Mitochondrial dysfunction and altered cellular bioenergetics consistently emerge in metabolomic investigations"

Screenshot from Science for ME update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Omics-based computational approaches for biomarker identification, prediction, and treatment of Long COVID — Sindy Pinero et al. "several biological findings demonstrate remarkable consistency across independent cohorts and platforms. Complement cascade dysregulation, particularly involving the C1Q, C3, and C5 components, appears to be reproducible across proteomic studies using various quantification methods. Mitochondrial dysfunction and altered cellular bioenergetics consistently emerge in metabolomic investigations, regardless of the platform or statistical approach."
Tom Kindlontomkindlon@disabled.social
2025-12-18

From the Netherlands:

Exaggerated IFN-I Response in Long COVID PBMCs Following Exposure to Viral Mimics

link.springer.com/10.1007/s108

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Exaggerated IFN-I Response in Long COVID PBMCs Following Exposure to Viral Mimics — Humer et al. "our data indicate that PBMCs from LC patients exhibit an hyperresponsive IFN-I response following activation by viral mimics that trigger RIG-I and cGAS. The exact underlying mechanism that drives this requires further investigation"
Tom Kindlontomkindlon@disabled.social
2025-12-18

From the US

Long COVID involves activation of proinflammatory and immune exhaustion pathways

nature.com/articles/s41590-025

Screenshot from latest Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Long COVID involves activation of proinflammatory and immune exhaustion pathways — Aid et al. "participants with LC exhibited reduced granzyme B and cytotoxic T cell signaling and increased immune exhaustion, suggesting dysregulated cross-talk between the innate and adaptive immune responses" "We also found that chronic upregulation of IFNγ signaling was associated with LC and correlated with signatures of reduced T cell activation and increased T cell exhaustion, suggesting that chronic immune stimulation may lead to functional impairment of T cells."
Tom Kindlontomkindlon@disabled.social
2025-12-17

Patterns of long COVID symptoms among healthcare workers in the UK and variations by sociodemographic, clinical and occupational factors: a cross-sectional analysis of a nationwide study (UK-REACH)

journals.sagepub.com/doi/10.11

Screenshot from Science for ME update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Patterns of long COVID symptoms among healthcare workers in the UK and variations by sociodemographic, clinical and occupational factors: a cross-sectional analysis of a nationwide study (UK-REACH) — Amani Al-Oraibi et al. "The gender disparities observed in the study, with female HCWs being disproportionately affected by neurocognitive, neurologic and gastrointestinal symptoms […] could be attributable to sex-based differences in immune responses and hormonal influences, which may affect symptom manifestation, differences in reporting and recovery."
Tom Kindlontomkindlon@disabled.social
2025-12-17

2/
From Spain:

Occupational determinants of Long COVID in the population-based COVICAT cohort

oem.bmj.com/content/early/2025

Screenshot from latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

Occupational determinants of Long COVID in the population-based COVICAT cohort — Sara De Matteis et al. Prospective study. "Among 2054 workers (1308 women, 746 men) aged 40–69 years, 486 developed LC (23.7%)." "The main drivers of increased risk were close contact with colleagues and the public […], no social distance at workplace […], rare or no use of facemask […] and commute by public transport"
Tom Kindlontomkindlon@disabled.social
2025-12-17

News Release 16-Dec-2025

Occupational factors strongly influence long-COVID risk

A large Catalan cohort study shows that healthcare, social care, education, retail, and transport workers are at higher risk for Long-COVID

eurekalert.org/news-releases/1

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

News Release 16-Dec-2025 Occupational factors strongly influence long-COVID risk A large Catalan cohort study shows that healthcare, social care, education, retail, and transport workers are at higher risk for Long-COVID Peer-Reviewed Publication Barcelona Institute for Global Health (ISGlobal) Work-related factors play a significant and independent role in the risk of developing Long-COVID, shows a new study based on the COVICAT cohort and led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by “la Caixa” Foundation, in collaboration with the University of Turin and the Germans Trias i Pujol Institute (IGTP). The findings, published in BMJ Occupational & Environmental Medicine, highlight that a substantial share of Long-COVID could be prevented through targeted workplace measures and policies.
Tom Kindlontomkindlon@disabled.social
2025-12-16

From NCNED, Australia:

News Release 15-Dec-2025

COVID-19 does not just affect the respiratory system, but also significantly alters the brain in people who have fully recovered from the infectious disease,
eurekalert.org/news-releases/1

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

News Release 15-Dec-2025 COVID-19 leaves a lasting mark on the human brain COVID-19 does not just affect the respiratory system, but also significantly alters the brain in people who have fully recovered from the infectious disease, highlighting the long-term neurological impact of the virus. Peer-Reviewed Publication Griffith University COVID-19 does not just affect the respiratory system, but also significantly alters the brain in people who have fully recovered from the infectious disease, highlighting the long-term neurological impact of the virus. Researchers from Griffith University’s National Centre for Neuroimmunology and Emerging Disease (NCNED) used advanced MRI techniques to ascertain the neurological implications of COVID-19 compared with those who had never been infected.
Tom Kindlontomkindlon@disabled.social
2025-12-16

News Release 15-Dec-2025

"Who is more likely to get long COVID? New study uncovers the genetic drivers behind the disease"

eurekalert.org/news-releases/1

"Integrative multi-omics framework for causal gene discovery in Long COVID"
journals.plos.org/ploscompbiol

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

News Release 15-Dec-2025 Who is more likely to get long COVID? New study uncovers the genetic drivers behind the disease Peer-Reviewed Publication University of South Australia Australian scientists have identified the key genetic drivers behind long COVID, revealing why some people continue to experience debilitating symptoms long after their initial infection. The breakthrough, made using large scale biological datasets, could pave the way for targeted treatments and personalised diagnostics.
Tom Kindlontomkindlon@disabled.social
2025-12-13

From Sweden:

Health outcomes in hospitalised and non-hospitalised individuals after COVID-19, an observational, cross-sectional study

nature.com/articles/s43856-025

Screenshot from Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid
#POTS @pots

Health outcomes in hospitalised and non-hospitalised individuals after COVID-19, an observational, cross-sectional study — Nygren-Bonnier et al. "Both groups were represented among those with more severe residual impairments and complex symptom panorama, but non-hospitalised patients had a higher proportion of cardiovascular dysautonomia, particularly POTS."
Tom Kindlontomkindlon@disabled.social
2025-12-13

From Switzerland

"persistently low work ability among those with severe health impairment point to a subgroup of people who are at a risk of experiencing longer-term occupational limitations"

thelancet.com/journals/lanepe/

Screenshot from Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver @novid #novid

Work ability trajectories and sick leave in individuals with post COVID-19 condition: 3-year follow-up of a population-based cohort — Tala Ballouz et al. "While some improvements were observed among those with moderate health impairment, persistently low work ability among those with severe health impairment point to a subgroup of people who are at a risk of experiencing longer-term occupational limitations."
Tom Kindlontomkindlon@disabled.social
2025-12-13

From the UK:

Feasibility of predicting next-day fatigue levels using heart rate variability and activity-sleep metrics in people with post-COVID fatigue

frontiersin.org/articles/10.33

Screenshot from Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Feasibility of predicting next-day fatigue levels using heart rate variability and activity-sleep metrics in people with post-COVID fatigue — Aboagye et al. "This pilot study has demonstrated the feasibility of using machine learning approaches to predict next-day fatigue levels in individuals with post-COVID fatigue based on objective physiological and behavioral metrics from wearable devices."
Tom Kindlontomkindlon@disabled.social
2025-12-13

From the UK:

Robust antibody and T cell responses tracked longitudinally in patients with long COVID

microbiologyresearch.org/conte

Screenshot from Science for ME weekly update

#Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Robust antibody and T cell responses tracked longitudinally in patients with long COVID — Marina Metaxaki et al. "Our findings demonstrate that long COVID patients maintain a robust functional immune status with no evidence of immune deficiency based on clinical symptomatology and immune molecular assessment."
Tom Kindlontomkindlon@disabled.social
2025-12-13

From the US (Maryland)

Structural brain abnormalities and neuropsychiatric symptoms in post-COVID condition

degruyterbrill.com/document/do

Screenshot from Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Structural brain abnormalities and neuropsychiatric symptoms in post-COVID condition — Meghann Ryan et al. "Structural brain abnormalities, with thicker cortices and larger volumes and surface areas, suggest compensatory processes such as enhanced myelination and neurogenesis rather than neuroinflammation" "these brain abnormalities and neurobehavioral symptoms tended to improve three years after infection."
Tom Kindlontomkindlon@disabled.social
2025-12-12

From Norway:

Brain MRI findings in patients with post COVID-19 condition: frequency and longitudinal changes in a nationwide cohort study

frontiersin.org/journals/neuro

Screenshot from Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Brain MRI findings in patients with post COVID-19 condition: frequency and longitudinal changes in a nationwide cohort study — Furevik et al. "A clinico-radiological gap exists between prevalent neurological and cognitive complaints and brain findings identified through standard imaging techniques. Advanced, quantitative neuroimaging analyses—not yet established in clinical practice—show potential for detecting subtle neuronal changes"
Tom Kindlontomkindlon@disabled.social
2025-12-12

2/
From Australia:

Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study

sciencedirect.com/science/arti

Screenshot from Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

@novid #novid

Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study — Thapaliya et al. "Our study identified altered signal intensity, abnormal tissue microstructure, and imbalanced neurochemicals in long COVID and COVID-19 recovered healthy controls. Importantly, we also found a significant association between T1w/T2w signal intensity and clinical measures, suggesting a potential link between myelin content and symptom severity."
Tom Kindlontomkindlon@disabled.social
2025-12-12

From the US:

Systems Immunology of Long Covid: Insights from the STOP-PASC Clinical Trial

medrxiv.org/content/10.64898/2

Screenshot from Science for ME weekly update

Hashtags:
@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Systems Immunology of Long Covid: Insights from the STOP-PASC Clinical Trial — Evan Maestri et al. "Despite considerable heterogeneity in LC, we have demonstrated via multicohort meta-analysis conserved dysregulation in inflammatory immune pathways. The proteins in the LCS Score which are consistently elevated in LC in multiple cohorts are associated with inflammation (IL6), monocyte (SIGLEC1/10) and neutrophil activation/granules (AZU1, PGLYRP1), and T/NK cell granzymes (GZMH, GZMA) suggesting a persistent dysregulated immune response."
Tom Kindlontomkindlon@disabled.social
2025-12-11

Integrative multi-omics framework for causal gene discovery in long COVID

journals.plos.org/ploscompbiol

Screenshot from Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
#Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #auscovid19 #CovidIsNotOver

Integrative multi-omics framework for causal gene discovery in long COVID — Pinero et al. "Most of the 32 genes are not strongly associated with individual symptoms when tested individually (AR is the only exception). However, their joint expression pattern reliably distinguishes patient subgroups, consistent with post-viral biology, in which pathway-level (not single-gene) dysregulation dominates."

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