Mark the date! The next Alpine conference on magnetic resonance in solids is planned for Sept 14-18 2025, as usual in beautiful #Chamonix-Mont-Blanc in the Alps. The invited speakers are listed on the conference website already: https://alpine-conference.org The registration opens early next year. #NMRchat #ssNMR

Slightly delayed due to my holidays, but excited to share this new paper that came out online a little while ago in ACS Applied Materials and Interfaces: https://doi.org/10.1021/acsami.4c08428 In it, PhD student Pushpa Rampratap spearheaded our effort to use MAS #NMR to study ECM-like #hydrogels. In a prior publication (https://doi.org/10.1016/j.carbpol.2023.121063) she described methods for preparing 13C enriched version of the polysaccharide hyaluronic acid…. #glycotime #nmrchat #ssnmr

Among many other topics, you can find discussion of how #SSNMR is particularly useful to understand the surface features of protein aggregates (their fuzzy coat), which are often hard to see by cryo-EM and other techniques. (2/2)

Our latest (review) article is now available online: https://doi.org/10.1042/BST20230731 in the journal Biochemical Transactions. In this invited article “Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation”, I have reviewed the contributions that solid-state #NMR #SSNMR has made to our understanding of the mutant protein aggregates in #huntingtonsdisease and related #polyQ disorders. (1/2)

Photo from yesterday’s official opening of the new CryoMAS #ssNMR platform in #umea (Sweden). Great talks covering all aspects of #ssnmr and its diverse applications.

Call for papers! Solid-State NMR and DNP of Heterogeneous Biomaterials and Cellular Systems https://www.sciencedirect.com/journal/solid-state-nuclear-magnetic-resonance/about/call-for-papers#solid-state-nmr-and-dnp-of-heterogeneous-biomaterials-and-cellular-systems -… #NMRchat #SSNMR

Busy week coming - but am definitely looking forward to next week visiting #Cambridge (UK) to discuss #amyloid #ssNMR #ECM #polysaccharides and more. Actually my first visit there, although I spent quite a few years in the 'other' Cambridge (MASS/USA). :-)

Chamonix hike during the #alpineMR2023 conference #ssNMR #nmrchat

Onderweg naar een congres dat totaal gewijd is aan vast stof #NMR! Het is in Chamonix (in de Alpen). #alpineMR2023 #ssNMR

Don’t miss the #iupacchains2023 parallel session 10 on Structural Biology and Protein Design at 10:20am - see the talk by my PhD student Raffaella Parlato! She will talk about our work with Wiktor Szymanski’s team (also University of #Groningen) - enabling #photochemical control over #polyQ #amyloid formation & structure. #ssNMR #chemistry

… using in-depth #moleculardynamics simulation to integrate various experimental constraint provides an unprecedented view of the structure of the misfolded protein aggregates, with a central role (of course) for new and existing #ssNMR data. These #polyQ protein fibrils are tough for #cryoEM due to structural and dynamic heterogeneity.
….

... forgot the screenshot of their modeling the air flows in their 3D printed stator design. #nmrchat #ssnmr

Cool new paper from Joern Schmedt auf der Guenne and coworkers, in the journal #SSNMR: “High resolution solid-state #NMR on the desktop”, presenting a conical MAS rotor design for use in permanent magnets. Looks cool! The team includes Oliver Pecher and Marco Braun from the NMR-service company, which is doing various other interesting things when it comes to #ssNMR hardware! https://www.sciencedirect.com/science/article/pii/S0926204023000346

Well, just got back from the FASEB protein aggregation conference #PACSRC in Ireland. As usual, it was a great event with a never-ending stream of cool science. Quite a few #amyloid structures discusses, based on #ssNMR and #cryoEM . I briefly talked about our own integrative structural biology work on the fibrils made by mutant huntingtin fragments #huntingtonsdisease , as well as our work with aggregation inhibitors (and how they reveal features of the aggregation mechanism) #polyQ

Abstracts for the alpine conference on magnetic resonance in solids are almost due!! Getting into the mood.. #nmrchat #ssnmr

Coming on May 30th: online webinar by Dr. Kaustubh Mote from the Tata Institute of Fundamental Research (TIFR) #hyderabad on the topic of “Measuring dynamics using anisotropic interactions in MAS-NMR”. More info: https://www.globalnmr.org/upcoming-talks Register to attend here: https://www.globalnmr.org/weekly-registration

#NMR #nmrchat #ssNMR #dipoles #dynamics #biophysics

Nuclear spin diffusion under fast magic-angle spinning in solid-state #nmr by Lewandowski and colleagues, in the journal of chemical physics: https://pubs.aip.org/aip/jcp/article/158/18/184201/2890210/Nuclear-spin-diffusion-under-fast-magic-angle #nmrchat #ssNMR

New Diamond Rotors for #ssNMR. By Griffin and colleagues. #nmrchat https://www.sciencedirect.com/science/article/abs/pii/S1090780723001106

New collaborative article now available online: "A Universal Nanogel‐Based Coating Approach for Medical Implant Materials" in the journal Advanced NanoBiomed Research. With the group of Patrick van Rijn #BME #UMCG and others. See: https://onlinelibrary.wiley.com/doi/10.1002/anbr.202200141 We contributed some #ssNMR analysis of the nanogel to probe its composition and modification. #nmrchat #nanomaterials

A new preprint from the lab (together with Marthe Walvoort's group) is now on #bioRxiv : https://www.biorxiv.org/content/10.1101/2023.03.16.532902v1 This manuscript presents nice work by Pushpa Rampratap, who did a great job figuring out how to make 13C-enriched hyaluronic acid #polysaccharide for use in #ssNMR . More forthcoming on the applications, but this paper introduces the protocols for producing the high-molecular weight HA. Enjoy! #glycotime #nmrchat #TeamMassSpec (Feedback welcome!)