Lmst

#studydesign

Manuscript c4,000 words
Review c2,700 words
5hrs

Paper in a key area of my methodological work, so it was really interesting. But I really needed to get stuck in.

Two collaboration projects on the design and reporting of #RCTs that might be useful for others:

https://pubmed.ncbi.nlm.nih.gov/37982521/
presents 19 factors to aid trial design, and the DELTA2 Guidance specifying a target difference and reporting the #SampleSize calculation for RCTs
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2884-0

#StudyDesign

A summary of strengths and limitations of randomized controlled trials and other types of study designs.

https://www.acsh.org/news/2025/12/02/rcts-not-end-all-be-all-49847

#Science #StudyDesign #RCT

This article offers a good discussion of covariate adjustment in cluster randomised trials:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12550654/

There are some good other resources out there, but this one is especially handy due to the breadth of topics covered:
statistical precision, bias from differential recruitment or missing data, how to select covariates, model-based approaches, missing data techniques, and illustration in a case study.

#RCT #Trials #StudyDesign

Master observational study designs—cohort, case-control, and cross-sectional—for evidence-based research and clinical decision-making. #ObservationalStudies #Epidemiology #StudyDesign #CohortStudy #CaseControlStudy #CrossSectionalStudy #MedicalEducation #USMLE #ResearchMethods #EvidenceBasedMedicine

https://mymedschool.org/portfolio/u01-06-001-observational-studies/?utm_source=mastodon&utm_medium=jetpack_social

A review of UK MHRA protocols (k=122) of the use of #Estimand -s offers insights for improvement of protocols due to incomplete or incorrect specifications:
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-025-08991-8

#RCT #StudyDesign #Registration #Causality

Further resources:

How estimands support stating the exact research question of a study and the interpretation of results:
https://www.bmj.com/content/384/bmj-2023-076316

Application of the estimand framework to for studies with Patient-Reported Outcomes:
https://jpro.springeropen.com/articles/10.1186/s41687-020-00218-5
#HRQOL

Which #SampleSize to use in your pilot or feasibility trial?

Well, you won't find the answer in this review of studies in #ISRCTN (2013 to 2020)
https://pilotfeasibilitystudies.biomedcentral.com/articles/10.1186/s40814-023-01416-w

But it is a good intro into the topic, and with 57% not reaching their target sample size, they may interestingly not provide the information they were designed to offer!

#StudyDesign #RCT

The first rule of #PostDoclife is:
Try not to go crazy #worklifebalance #mentalhealth

The second rule of #Postdoclife is:
Do something useful for science #studydesign #deepwork #methodology #scientificsoftwaredevelopment
#hardworkisrare #focusisprecious

The third rule of #Postdoclife is:
Tell others the cool thing you did #writepapers #outreach #presentations

Go to rule 1.

#AcademicChatter #Astrodon

Thank you to #HealthPsychology and Behavioral Medicine @unibern for writing a post about the recent Summer Course 2025, “Contemporary Evaluation of Interventions: Mobile, Digital, and Pragmatic”
https://www.linkedin.com/posts/gesundheitspsychologie-und-verhaltensmedizin-gpv-unibe_gpv-unibe-mhealth-activity-7340302148112408577-4_JW/

#StudyDesign #RCT #HiddenCurriculum #ECRs

A well-justified epistemological foundation is a key requirement for a #DelphiStudy:
https://www.sciencedirect.com/science/article/pii/S1865921722000769

The team argues that #ReportingGuidelines encourage researchers to reflect on and disclose key assumptions and methodological choices in such studies.

#StudyDesign #Consensus

Co-developed at #DundeeUni and #SFU
"A Toolkit for Building a Collective of Older Adult Researchers"
https://www.sfu.ca/starinstitute/about/institute-activities/research-project--coar.html
(COAR)

"A practical resource for engaging older adults as active partners in community-based research"

#Participatory #StudyDesign

Research participants being fully informed about the research and to provide their voluntary consent to participate is a cornerstone of ethical research practice.

Secondary school pupils in Cameroon explored how to engage with consent principles, main focus were benefits and risks of participation, #VoluntaryParticipation, and confidentiality
https://journals.sagepub.com/doi/full/10.1177/17470161251335709

#ResearchEthics #StudyDesign #ParticipatoryResearch

Mirjam Stieger (Lucerne Uni) and I are invited to present
"Contemporary #Evaluation of Interventions: Mobile, Digital, and Pragmatic"
at @unibern
https://www.bbs.unibe.ch/training/summer_course/index_eng.html

This is the annual Summer Course of the Doctoral Program Brain and Behavioral Sciences, and comprises a mixture of keynotes, masterclasses, hidden curriculum etc.

I am very much looking forward to it, and also very honoured to be invited once again to Bern to train #ECRs!

#RCT #EvaluationResearch #ResearchDesign #StudyDesign

🧪 🛟 In this CPH Focus: Explore the essentials of randomized controlled trials (RCTs)—the gold standard in experimental study designs for evaluating interventions—crucial for public health and clinical research. Link: https://buff.ly/48GZbnT #CPH #PublicHealth #StudyDesign #EpiSky #MedSky
https://buff.ly/48GZbnT

Tutorial paper illustrating how to develop planned contrasts (as an alternative to #PostHoc comparisons) in #Rstats, including empirical examples with reproducible data:
https://journals.sagepub.com/doi/full/10.1177/25152459241293110

#StudyDesign #RCT

🎄Day 9🎄Master #fNIRS Research with Proven #BestPractices 📘
Stay informed and enhance the quality of your studies by following these best practices for fNIRS research. From study design to data reporting, this guide provides valuable insights to help you publish impactful research.
🎁✨ Ready to refine your approach? https://doi.org/10.1117/1.NPh.8.1.012101

#ArtinisAdventCalendar #Research #StudyDesign