Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry
https://www.medrxiv.org/content/10.1101/2024.05.17.24307553v3?ct=
"our findings indicate that thromboembolic pathways may contribute to #longCOVID independently of acute disease severity"
#TeamClots @longcovid
#PwLC #PostCovidSyndrome #LC #PASC #postcovid #CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver #auscovid19
my lovely friend 🐾@angryhacademic now also has an fb page dedicated to
#longcovid #postvac #MECFS #POTS #MCAS #teamclots #chronicillness #CovidIsntOver
🖖🏾
2/
"in the rat models, the concentration of microthrombus is reduced by more than 60% in 3 minutes"
Hashtags:
@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver #auscovid19 @auscovid19 #TeamClots
Interventional Removal of Travelling Microthrombi Using Targeted Magnetic Microbubble
https://onlinelibrary.wiley.com/doi/10.1002/adhm.202401631
"In this work, an interventional method is developed to identify & remove the traveling microthrombi using targeted-magnetic microbubbles (TMMBs) & an interventional magnetic catheter”
@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 #TeamClots
1/
2/
"Our study revealed that NETs may be a component of circulating FAM, suggesting that higher NETs formation promotes the stabilization of FAM in the circulation, leading to deleterious effects which (in part) may contribute to the symptoms of LC."
Hashtags:
@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
#LongCovid #TeamClots
New pre-print:
Circulating microclots are structurally associated with Neutrophil Extracellular Traps and their amounts are strongly elevated in long COVID patients
https://www.researchsquare.com/article/rs-4666650/v1
====
Hashtags:
@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid #CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver #auscovid19 @auscovid19
#TeamClots
1/
3/
New pre-print:
Flow Clotometry: Measuring Amyloid Microclots in ME/CFS, Long COVID, and Healthy Samples with Imaging Flow Cytometry
https://www.researchsquare.com/article/rs-4507472/v1
Hashtags:
@longcovid
#LongCovid #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #PASC #COVIDBrain
#TeamClots @mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @covid19
2/
Microclot concentrations determined by the present cell-free flow clotometry technique for the three cohorts
from
Flow Clotometry: Measuring Amyloid Microclots in #MECFS, #LongCOVID, & Healthy Samples with Imaging Flow Cytometry
https://www.researchsquare.com/article/rs-4507472/v1
#TeamClots #CFS #PwME @longcovid @mecfs @covid19
🧵
New pre-print:
Flow Clotometry: Measuring Amyloid Microclots in ME/CFS, Long COVID, and Healthy Samples with Imaging Flow Cytometry
https://www.researchsquare.com/article/rs-4507472/v1
=========
@longcovid
#LongCovid #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #PASC #COVIDBrain
#TeamClots #MEcfs #CFS #PwME @mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2
1/
Should those affected run for public office?
If COVID-19 typically causes cognitive decline, increased aggression, and reduced risk aversion, should those affected run for public office? Microclot testing, a valid indicator of past COVID-19 infection, might explain its unavailability in Canada.
2/
A detailed article giving varying perspectives of scientists on the validity of the hypotheses, and the need for clinical trials of treatments currently being sold to patients.
Hashtags:
@longcovid
#LongCovid #PwLC #PostCovidSyndrome #LC #PASC #postcovid
#CovidBrain
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid #novid #CovidIsNotOver #auscovid19 @auscovid19
Increased fibrinaloid microclot counts in platelet-poor plasma are associated with #LongCOVID
Replication study of microclots by a UK team using an automated quantification method and refining sampling handling to reduce the potential for processing artifacts
#TeamClots @longcovid
#PwLC #PostCovidSyndrome #LC #PASC #postcovid
@covid19 #COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid #novid #CovidIsNotOver #CovidBrain @auscovid19
Possible Role of Fibrinaloid Microclots in Postural Orthostatic Tachycardia Syndrome (POTS): Focus on Long COVID
Free full text:
https://www.mdpi.com/2075-4426/14/2/170
#teamclots @longcovid
#LongCovid #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #PASC
@covid19 #Coronavirus
#COVIDー19 #COVID19 #COVID #COVID_19 #SARSCoV2 @novid #novid #CovidIsNotOver #COVIDBrain
@auscovid19
Newly announced upcoming clinical trial:
"A clinical trial to test if the fibrinolytic enzyme Lumbrokinase improves symptoms and mitigates blood clotting issues or platelet hyperactivation in patients with #LongCOVID, ME/CFS, & LongLyme disease."
https://polybio.org/projects/lumbrokinase-longcovid-me-cfs-clinical-trial/
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #TeamClots @longcovid
#PwLC #postcovid #postcovid19 #LC #PostCovidSyndrome #longhaulers #PASC
@covid19 #Coronavirus
#COVID19 #COVID #SARSCoV2
Good news! My microclots are no longer severe! I’m in the safe zone after 8 months of TT then DT 🎉
Thanks much to #TeamClots for confirming suspicions many of us had + my Long Covid microclot doctor for the assist! Hope it stays this way as long as possible
June 2023 versus February 2024
#MECFS #LongCovid
3D Holo-Tomographic Mapping Of #Covid19 Microclots In Blood To Assess Disease Severity
https://pubs.acs.org/doi/10.1021/cbmi.3c00126
“the label-free DHTM-based approach demonstrated in our study could serve as a powerful tool for screening microclots in plasma.”
#TeamClots @covid19
#COVIDー19 #COVID19 #COVID_19 #SARSCoV2 #novid #CovidIsNotOver #CovidBrain
Not a #LongCovid study but the tool may be useful to investigate it.
3/
“We will offer a £25 Love2Shop voucher for each participant who provides a blood sample”
#MEcfs #MyalgicE #CFS #PwME #MyalgicEncephalomyelitis #ChronicFatigueSyndrome #TeamClots
@mecfs #sheffield #sheffieldfolk
2/
People interested in this research might be interested in this talk, "Vascular pathology in post-viral conditions: the role of #Microclots" by Dr Nolan &
@resiapretorius from last December
https://www.youtube.com/watch?v=uDbwNFBz7Y8
#TeamClots #MEcfs #CFS #PwME #LongCovid #PwLC #postcovid @mecfs
Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to #SARSCoV2 Infection
“We have also demonstrate the fine balance between coagulation & fibrinolysis could be readily impaired & identified a possible role of Annexin A2 in coagulopathy developed after #SARSCoV2 infection”
@longcovid
#LongCovid #PwLC #LC #PASC #postcovid @covid19
#COVIDー19 #COVID19 #COVID #TeamClots
Fibrin microthrombi in bladder urothelium after #SARSCoV2 infection: Case report
“this study suggest[s] increased levels of IL-8 in the bladder may drive microthrombi in the bladder vasculature & urinary IL-8 levels might provide a means of detecting if a patient is at risk for developing symptoms from these microthrombi after SARS-CoV-2 infection”
#TeamClots #MicroClots @longcovid
#LongCovid #PwLC #LC #PASC #postcovid
#COVIDー19 #COVID19 #COVID
