Researchers observe how the flexibility of a #protein_hinge is crucial to the transfer of #cell proteins.

#Ubiquitination

https://phys.org/news/2024-01-flexibility-protein-hinge-crucial-cell.html

#Review: 'Deciphering the protein ubiquitylation system in plants'

🧬 F-box genes have roles in #ubiquitination and control many processes in #plants.
🧬 Here, a deleterious F-box duplication #model is presented.

https://doi.org/10.1093/jxb/erad354

This #review summarises how pathogenic #effectors can mimic or target the highly conserved #ubiquitin–#proteasome system to disrupt cellular processes in their #plant hosts.

https://doi.org/10.1093/jxb/erad191

#ubiquitination #immunity #PAMP #effector

What can bacteria teach us about unexplored areas of #ubiquitin signaling and regulation?
John Pruneda and colleagues discuss how #pathogens subvert the host cell #ubiquitination system by either adopting or breaking its rules
New review article as #weekendreading!

https://www.embopress.org/doi/full/10.15252/embj.2023114318

#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481

Mutations in PARK15/FBXO7 cause #ParkinsonsDisease. @alsanchezmar @Aitor_Mtz & @whitworth_lab shows that its fly ortholog works antagonistically with USP30 to set the #ubiquitination threshold needed to regulate basal #mitophagy #PLOSBiology https://plos.io/3qfaUZ1

How are specific dysfunctional #mitochondria removed under steady-state conditions?

Julia Pagan and coworkers (University of Queensland) show that an #SCF #ubiquitin #ligase based on #FBXL4, mutated in #MTDPS13, limits basal #mitophagy via #ubiquitination of #NIX and #BNIP3 receptors

https://www.embopress.org/doi/10.15252/embj.2022112767

A #protelysis cascade fine-tunes homologous #recombination repair in plants:
Arp Schnittger and coworkers show #KNOTEN1, stabilized by #UBP12/13, triggering K63-linked #ubiquitination and #autophagic degradation of #BLM complex subunit #RMI1 upon #DNAdamage

https://www.embopress.org/doi/10.15252/embj.2022111980

Surprising interplay between #SMC5/6 and #transcription-regulating #PAF1 complexes in #Arabidopsis #DNAdamage response:
Shunping Yan and colleagues find them to interact and recruit E2/E3 enzymes for #histone H2B #ubiquitination at DNA double-strand breaks
https://www.embopress.org/doi/10.15252/embj.2022112756

Granted, the test case is—you guessed it—#BRD4. Nevertheless, this could be an exciting new #TPD modality if it is generalizable to other target proteins, such as those lacking accessible lysines or for which #ubiquitination is slow or inefficient.

K63 #Ubiquitination of #YAP by SKP2 #E3Ligase⏫its nuclear import🤠

Synergized with mTORC1-PERK-ATF4 axis in renal #Cystogenesis🐭#JuvenileCysticKidney #Ciliopathy

A #CellCycle-specific regulation of YAP?😆

Dr. Andrew Karaplis lab JCI 2022
https://www.jci.org/articles/view/153943