#webservices

PPC Landppcland
2025-06-30

ICYMI: Russian ISPs throttle Cloudflare traffic to 16KB: Russian Internet Service Providers implement traffic caps that disrupt digital marketing infrastructure across major web services. ppc.land/russian-isps-throttle

2025-06-11

June 2025 WikiPathways release: 338 edits by 15 contributors and 9 new pathways. data.wikipathways.org/

Accessible via #webservices, #rstats, Pathvisio, and Cytoscape.

Depiction of the pathway "Lupus pathogenesis" (WP5559): "Systemic lupus erythematosus (SLE) is an autoimmune disease in which the body’s immune system mistakenly attacks its own tissues. It can lead to lupus nephritis, where the kidneys become inflamed. This causes impaired kidney function and, in severe cases, kidney failure. Lupus has an incidence of around 5 per 100,000 person-years, and affects women much more frequently than men. ..."Depiction of the pathway "Atopic dermatitis mechanism and therapies" (WP5538): "Atopic dermatitis (AD), also known as atopic eczema, arises from a complex interplay of genetic susceptibility and environmental triggers that disrupt the skin barrier. This dysfunction is exacerbated by alterations in the skin microbiome—particularly a reduction in Staphylococcus epidermidis and an overgrowth of Staphylococcus aureus—which increase the skin’s vulnerability to external allergens. Keratinocytes, in response to this disruption, release epithelial-derived cytokines such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33. These cytokines promote type 2 immune responses by activating group 2 innate lymphoid cells (ILC2s), T helper 2 (Th2) cells, and T follicular helper 2 (Tfh2) cells. ..."Depiction of the pathway "Lupus therapies" (WP5560): "Therapeutic approaches in systemic lupus erythematosus (SLE) increasingly focus on modulating B and T cell activity. B cell–directed therapies involve targeting specific surface receptors such as CD19, CD20, CD22, CD38, and CD40, as well as blocking B cell-related cytokines like BAFF (B-cell activating factor, also known as TNFSF13B). T cell-focused strategies include blocking co-stimulatory pathways (e.g. CD40–CD40L, CD80/86–CD28, ICOS–ICOSL) and inhibiting pro-inflammatory cytokines, including IL-6, IL-12, IL-17, IL-23, and IFN-γ. Inspired by Figure 1 in Su et al. (2024)."

🧠 L’Inist était à la #JDLS2025 !
Hier, lors de la Journée Deep Learning pour la Science, Léo Gaillard & Lucas Anki (Istex TDM, Inist) ont présenté un poster sur des web services de deep learning pour enrichir des métadonnées 📊
👉 services.istex.fr
#JDLS2025 #IA #DeepLearning #ScienceOuverte #Inist #ISTEX #WebServices

2025-05-26
Hi, I'm Evan (he/any).

TLDR: I'm a privileged white hetero-cis-male politically #left #TriratnaBuddhist #SoftwareEngineer (#IHelpPeopleGetJobs) currently in #Seattle but planning to move to #AotearoaNZ or #Australia as so as we can manage it with my wife & 3 kids

I'm politically #left (at least in United States terms). I'm a #voting nerd in that I have a favorite voting-related textbook (Collective Decisions and Voting by Nicolaus Tideman).

I think we could mostly solve #gerrymandering by making larger districts with ~5 representatives instead of just 1 and then using #SingleTransferableVote. That would strike a nice balance between local & proportional representation. For single-person positions, like presidents/governors/mayors, STV becomes #RankedChoiceVoting (aka #InstantRunoffVoting aka #AlternativeVote) which eliminates the spoiler effect and leads to more civil campaigns.

Plus, #RankedChoiceVoting eliminates the need for primaries and runoffs, which can lead to significant cost reductions.

I'm training for ordination with the #TriratnaBuddhist Order (#dhamma, #dharma, #Buddhism) and have been for many years. It's a long process, especially with other things going on. I've done some kind of #meditation (mostly #anapanasati) every day for over 3 years and more sporadically since 2006.

That said, I do take issue with some of the things the founder (Sangharakshita) did, and I'm concerned with a recent rise in sort of guru worship around. I can have gratitude for his explanation of the dharma, try to sort out the idiosyncratic bits, and still view him as a deeply flawed human being.

I write #software for http://indeed.com (job search site) (previously employed by Amazon). I've written a lot of #database-backed #webservices in #Java, but in the last few years, I've been working on #microfrontend platforms in #JavaScript & #TypeScript, primarily supporting #React. I have more knowledge about #Webpack #ModuleFederation than anyone should be cursed with. I'd love to try #SolidJS, #RustLang seems really cool, and I'm excited about the future of #WebAssembly.

My wife & I have fantasized about moving to #AotearoaNZ or #Australia since well before the pandemic, and now we're actively trying make it happen. Since we're both in high-demand professions (she's a nurse), I think it should go reasonably smoothly 🤞. Feel free to get in touch with job opportunities that offer visa sponsorship, suggestions for #kiwiana or Australian culture that will help us adapt, reasons that your city is the best, etc. I always blow on the pie when I wear my jandals to the dairy. If we ship things over, I can only hope that the front doesn't fall off the boat. I hear that only rarely happens.

My daughter Juniper was born at the beginning of 2020, so her experience of life and my experience of parenthood are both tightly linked to the pandemic. On the upside, I get to work remotely, which means I get more time with her. She's a lot of fun (and of course a lot of work).

Then, we had our twins Heath & Magnolia (Noli) in September 2023, and our lives got even more hectic and full of love.

Juniper goes to a Waldorf school, and I wish I could go, too, but I think the adult version of Waldorf school might just be therapy.
Jens Oliver Meiertj9t@mas.to
2025-05-26

If you’re in the mood for web services today, check out @frontenddogma’s web services archives! 😬

frontenddogma.com/topics/web-s

#webdev #webservices

2025-05-11

May 2025 WikiPathways release: 491 edits by 9 contributors and 8 new pathways.

Accessible via #webservices, #rstats, Pathvisio, and Cytoscape.

#biology #bioinformatics

Image of the Visual cycle (WP5534) pathway. https://www.wikipathways.org/pathways/WP5534

Description: 

"The visual cycle, also known as the retinoid cycle metabolic pathway, regenerates vitamin A derived chromophore 11-cis retinal. This enables visual phototransduction response to light. Inspired by rgd.mcw.edu/rgdweb/pathway/pathwayRecord.html?acc_id=PW:0001005."Image of the Atopic dermatitis mechanism and therapies (WP5538) pathway. https://www.wikipathways.org/pathways/WP5538

Description: 

"Atopic dermatitis (AD), also known as atopic eczema, arises from a complex interplay of genetic susceptibility and environmental triggers that disrupt the skin barrier. This dysfunction is exacerbated by alterations in the skin microbiome—particularly a reduction in Staphylococcus epidermidis and an overgrowth of Staphylococcus aureus—which increase the skin’s vulnerability to external allergens. Keratinocytes, in response to this disruption, release epithelial-derived cytokines such as thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33. These cytokines promote type 2 immune responses by activating group 2 innate lymphoid cells (ILC2s), T helper 2 (Th2) cells, and T follicular helper 2 (Tfh2) cells. These lymphocytes, stimulated by activated Langerhans cells (LCs) and inflammatory dendritic epidermal cells (IDECs), subsequently secrete IL-4, IL-5, and IL-13. IL-4 and IL-13 signal through type I (IL-4Rα / CD132) and type II (IL-4Rα / IL-13Rα1) receptors expressed on B cells, keratinocytes, and sensory neurons, activating the JAK-STAT signaling pathway. Tfh2 cells promote class switching to IgE in B cells, enhancing mast cell and basophil activation via FcεRI. [..]"Image of the Fibrotic response of human trabecular meshwork cells to transforming growth factor-beta 3 (TGFB3 and autotaxin (ENPP2, or ATX) in aqueous humor (WP5545) pathway. https://www.wikipathways.org/pathways/WP5545

Description: 

"This pathway visualises the potential mechanisms of TGF-β3-mediated ENPP2 (or ATX) expression and fibrotic changes in HTM cells. This pathway was created based on the PFOCR project, https://pfocr.wikipathways.org/figures/PMC9496180__biomolecules-12-01231-g008.html"Image of the Multiple sclerosis mechanism and therapies (WP5540) pathway. https://www.wikipathways.org/pathways/WP5540

Description: 

"This diagram shows the immunopathogenesis of multiple sclerosis (MS) and therapeutic targets. Available therapies for MS act through a range of mechanisms, including pleiotropic effects, immune cell depletion, inhibition of proliferation, and blockade of cell migration. These intervene at various stages of the inflammatory process. Treatments exert their effects across the peripheral immune system, the blood–brain barrier, and within the central nervous system (CNS) itself. Inspired by Figure 1 in Bierhansl et al. (2022)."
Larry GarfieldCrell@phpc.social
2025-05-06

English pronunciation is so weird. Like, it's spelled "GraphQL", but it's pronounced "SOAP."

#Programming #WebServices #humor

Josh “Yoshi” Vickersonjosh@vickerson.me
2025-04-25

Follow-up questions:

➡️ Aside from “work on the website” what did that person do? What else was their responsibility?

➡️ If you had to write a description for that title today in 2025, what responsibilities would you include?

#WebDevelopment #WebsiteManagement #Webmaster #JobTitles #AskFedi #WebServices #SysAdmin #AskFediverse

Josh “Yoshi” Vickersonjosh@vickerson.me
2025-04-25

Once upon a time, working on a website granted you the title of "Webmaster". As the Web evolved, more specialized roles took over and the title fell out of favor.

Searching for it now, I don't find many job listings for "Webmaster". So now I'm curious: how far removed from that job title are we?

When was the last time you heard of someone with “webmaster” as their actual job title?

#WebDevelopment #WebsiteManagement #Webmaster #JobTitles #Poll #AskFedi #WebServices #SysAdmin #AskFediverse

Tracey smithtraceypure
2025-04-25

Web Services That Make Your Brand Unstoppable

Boost your digital presence with Innoraft’s expert web services tailored for modern businesses. From intuitive UI/UX design to scalable development and seamless deployment, we deliver end-to-end solutions that drive results. Explore future-ready, secure, and high-performing web solutions with a team that understands your vision and builds for success.

Visit at: innoraft.ai/web

Dirk Dithardtdnet
2025-04-22

🛡️ Neue Muster-Richtlinie: Sicherer Betrieb von Webservices​

Unsere neue Richtlinie deckt den gesamten Lebenszyklus von Webservices ab – von der Planung bis zur Außerdienststellung.​

✅ Berücksichtigt:

ISO/IEC 27001

BSI IT-Grundschutz

DSGVO, BDSG​

🔗 wiki.isms-ratgeber.info/wiki/R

2025-04-10

:mega: April 2025 WikiPathways release: 454 edits by 10 contributors and 9 new pathways.

Accessible via #webservices, #rstats, Pathvisio, and Cytoscape. Supported by AWSOpen wikipathways.org/download.html

#biology #bioinformatics #openscience

new pathway: "Age-related macular degeneration (WP5526)"

"Age-related macular degeneration (AMD) is a leading cause of vision impairment in individuals aged 55 and older in the Western world. This diagram shows metabolic pathway crosstalk in AMD. In AMD, the upregulation of PARP2 expression leads to the downregulation of SIRT1. The depletion of SIRT1, a NAD+-dependent deacetylase, causes acetylation and inactivation of PGC-1α."new pathway: "Retinoid metabolism in retina: healthy vs. RLBP1-deficient (WP5532)"

"RLBP1 encodes CRALBP, a cellular retinaldehyde-binding protein that functions as a soluble retinoid carrier in the visual cycle of the eye. Mutations in RLBP1 are linked to recessively inherited conditions, such as Bothnia dystrophy, retinitis pigmentosa, retinitis punctata albescens, fundus albipunctatus, and Newfoundland rod-cone dystrophy."new pathway: "Aspirin prevention of cancer metastasis (WP5518)"

"Platelets generate TXA2, which binds to its receptor (TP) on T cells, initiating the activation of ARHGEF1, a guanine exchange factor that promotes the conversion of RhoA from its inactive GDP-bound state to its active GTP-bound form. This RhoA activation inhibits TCR-induced kinase pathways, T cell proliferation, and effector functions, ultimately suppressing anti-metastatic immunity. TXA2 production by platelets is COX1-dependent and can be blocked by aspirin or COX-1 selective inhibitors, which relieve T cells from TXA2-mediated suppression. Inspired by figure 14 in in Yang et al. (2025)."
eWebWorldewebworld
2025-03-27

AI & Web Development: A Perfect Match

Explore how AI-driven tools are streamlining development, optimizing UX, and making web design smarter and more efficient. More - ewebworld.in/web-development/

2025-03-27

Anyone know where there's a weather rss or web service to pull weather by zip code?

#weather #rss #webservices

2025-03-20

Il faut dorénavant une ETA pour voyager au Royaume-Uni depuis la France. gov.uk/guidance/apply-for-an-e
Ils insistent de ouf' pour qu'on installe leur app. Il y a quand même chaque fois la possibilité de le faire "online" (comprendre par un navigateur Web). Je viens de le fait sur mon tel à partir de Firefox et ça a bien fonctionné. Le scan de ma tête n'a pas satisfaisant, ça a été corrigé par l'upload d'une photo.
Je suis satisfait 😊
#webservices

Client Info

Server: https://mastodon.social
Version: 2025.04
Repository: https://github.com/cyevgeniy/lmst