Our September Issue is out! The cover image shows immunofluorescence staining of nuclei (DAPI, blue), pan-cytokeratin (red), and MHC-II (green) in metastatic lymph nodes in formalin-fixed paraffin-embedded specimens from breast cancer patients.

From Lei et al. (https://doi.org/10.1084/jem.20221847).

Read JEM September Issue: https://rupress.org/jem/issue/220/9

Our August cover shows a sagittal plane confocal image of a naive knee from CX3CR1-eGFP Ly6G-tdTomato double reporter mouse containing resident macrophages and no neutrophils (pan-macrophage CD68, cyan; lining macrophage VSIG4, magenta; CX3CR1, orange; nuclei, gray).
Zec et al. show that macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation (https://rupress.org/jem/article/220/8/e20220595/214068/Macrophages-in-the-synovial-lining-niche-initiate).
Read JEM’s August Issue: https://rupress.org/jem/issue/220/8

Oral TRM reactivation elicits gingival inflammation. Our July cover shows increased OT-I T cells (white) and pan-leukocytes (red) in buccal mucosa of a novel viral-prime, epitope-pull (VPEP) mouse model, after oral SIIN peptide swabbing. Nuclear and E-Cadherin staining are in green and purple, respectively.

from Stolley et al. (https://doi.org/10.1084/jem.20221853)

Read JEM’s July issue: https://rupress.org/jem/issue/220/7

On our June cover: DNASE1/DNASE1L3 double-knockout (DKO) mice were infected with S. aureus, and their kidneys were examined by immunohistochemistry 72 h later. Sections were stained with DAPI and antibodies against S. aureus (green) and Ly-6G (red). Shown is a low magnification of the entire kidney. From Lacey and colleagues: (https://doi.org/10.1084/jem.20221086).

Read JEM’s June Issue: https://rupress.org/jem/issue/220/6

On our May cover: Qin et al. (https://doi.org/10.1084/jem.20220776) develop a genome-editing tool that combines the versatility of prime editors and unconstrained PAM requirement of SpRY, which is able to rescue retina functionality and restore vision in mice. The cover shows a section of a Pde6bT to C mouse retina immunostained for GFP (green), rhodopsin (red), and nuclei (blue).

Read JEM’s May Issue: https://rupress.org/jem/issue/220/5

On our April cover: Petkova et al. (https://doi.org/10.1084/jem.20220741) identify a new Ptx3-positive immunoregulatory subtype of lymphatic endothelial cells, iLECs, that drive oncogenic PI3K-driven lymphatic malformations. The cover shows a developing dermal venule lesion in a Pik3ca transgenic mouse. The image has been modified by the JEM editorial office.

Read JEM’s April issue: https://rupress.org/jem/issue/220/4

On our March cover: Kaiser et al. show that regulatory T cells infiltrate sites of active viral infection and influence epithelial repair (https://bit.ly/3KMFS2l).

The image shows a lung section of a mouse infected with influenza-labeled (mCherry) virus and labeled Tregs (green) and stained for secreted extracellular matrix proteoglycan Agrin (white). The image has been modified by the JEM editorial office.

Read JEM’s March Issue: https://rupress.org/jem/issue/220/3

Gut microbiota biofilms: From regulatory mechanisms to therapeutic targets.

In this Viewpoint, Andre Buret and Thibault Allain discuss the mechanisms that regulate gut microbiota biofilms integrity and highlight the importance of studying phenotypic biofilm damage, beyond the characterization of relative bacterial abundance. https://rupress.org/jem/article/220/3/e20221743/213820/Gut-microbiota-biofilms-From-regulatory-mechanisms?utm_source=mastodon

The animal model for experimental encephalomyelitis, first published 90 yr ago, continues to illuminate mechanisms of disease. The model, initially developed to understand how smallpox triggers neuroinflammation on rare occasions, now moves full circle to its origins.

A Perspective from Lawrence Steinman, Roberto Patarca, and William Haseltine: https://rupress.org/jem/article/220/2/e20221322/213807/Experimental-encephalomyelitis-at-age-90-still?utm_source=mastodon

Our February cover shows a cortical section immunostained for CD31 and αSMA to identify capillary-like arteriovenous connections in mice.
Nielsen et al. (https://rupress.org/jem/article/220/2/e20211390/213722/Endothelial-Rbpj-deletion-normalizes-Notch4?utm_source=mastodon) show that brain arteriovenous malformations induced by constitutively active Notch4 in mice are normalized following deletion of the Notch signaling mediator Rbpj.
Read JEM’s February Issue: https://rupress.org/jem/issue/220/2?utm_source=mastodon

We're pleased to present a special collection highlighting recent immunology research articles. The collection covers a range of topics including immunometabolism, mucosal immunology, lymphocyte activation, immune cell differentiation and residency, inflammation, host-parasite interactions, tumor immunology and immunodeficiencies. We hope you enjoy reading the collection and welcome your feedback! https://rupress.org/jem/collection/21625/Immunology-Update-Winter-2023?utm_source=mastodon

@SaraSuliman is an assistant professor in the Department of Experimental Medicine at UCSF. Her lab uses multiple approaches to identify candidate tuberculosis (TB) risk pathways and to determine their role in TB progression. For our latest #PeopleAndIdeas, we caught up with Sara to talk about how she got interested in science, what she’s currently working on, and what she thinks about the future of academic science. https://rupress.org/jem/article/220/2/e20230038/213809/Sara-Suliman-Science-is-better-when-it-s?utm_source=mastodon

Defective microglial responses underlie many neurological disorders. In a recent study, Chadarevian et al. (https://rupress.org/jem/article/220/3/e20220857/213788/Engineering-an-inhibitor-resistant-human-CSF1R?utm_source=mastodon) designed a novel strategy that enables improved engraftment of human microglia.
New Insights from Adeline Walsh & John R. Lukens (University of Virginia): https://rupress.org/jem/article/220/3/e20222070/213806/Engineering-mighty-microgliaEngineering-mighty?utm_source=mastodon

New Review: The microbiome influences response to immunotherapy, including immune-related adverse events (irAEs) with checkpoint inhibitors. Wang, Jenq, et al. discuss microbiome contributions to irAEs by focusing on major bacterial taxa, potential immune mechanisms, and clinical opportunities for microbiome modulation to treat irAEs. https://rupress.org/jem/article/220/3/e20220948/213796/Microbiome-influencers-of-checkpoint-blockade?utm_source=mastodon

Our January cover shows the blood vascular network, immunostained with Isolectin B4 (white), in the retinae of 7-d-old mice pups. From Nakayama et al. (https://doi.org/10.1084/jem.20211628?utm_source=mastodon)
Read JEM’s January Issue: https://rupress.org/jem/issue/220/1?utm_source=mastodon

👋 Hello from Journal of Experimental Medicine (JEM)! We are pleased to present 2022: The Year in Experimental Medicine, our annual Best of JEM series highlighting cutting-edge research in immunology, host-pathogen interactions, cancer biology, tumor immunology, cardiovascular biology, neuroscience & more. We invite you to read these articles and to learn more about publishing in JEM: https://rupress.org/jem/collection/21566/2022-The-Year-in-Experimental-Medicine?utm_source=mastodon