I had an incredible time at #ACSSpring2025! The conference was filled with groundbreaking research and cutting-edge advancements in chemistry and biology, and I was truly amazed by the depth of innovation on display.

#ProudtobeaChemist #Chemistryheroes

I had an incredible time at the AAAS Annual Meeting 2025 in Boston! This was my first experience at a multidisciplinary conference, and I gained valuable insights from areas outside my own field.

I’m so grateful to be a part of the AAAS community! #AAASmtg

I'm excited to share our work on the discovery of novel selective Orai blockers.
https://www.sciencedirect.com/science/article/abs/pii/S022352342400686X?via%3Dihub

The Orai channel is one of the major components of the calcium release activated calcium (CRAC) channel. The CRAC channel is highly expressed in T lymphocytes and plays critical role in regulating T cell proliferation and functions.
In this work, we describe structure-activity relationships of a series of selective Orai channel blockers.

Receptor-interacting serine/threonine kinase 2 (RIPK2) is a dual-specific kinase downstream of NODs signaling pathway. RIPK2 plays important roles in both innate and adaptive immunities. This review summarizes the recent works in developing RIPK2 inhibitors and degraders. We also briefly describe RIPK2 structure and its functions.

https://www.frontiersin.org/articles/10.3389/fphar.2023.1127722/full

#RIPK2 #medicinalchemistry #autoimmunedisease #drugdiscovery #kinase #inhibitors