We discussed this nice preprint in journal club today, in which Taniel Winner (Berman, Ting, Kesar labs) comes up with a relatively simple procedure to identify and understand differences in walking gait between individuals (in this case, humans who had a stroke vs. those who did not). https://www.biorxiv.org/content/10.1101/2022.12.22.521665v1
They train recurrent neural networks to predict walking kinematics for each individual and then project the dynamical models onto a common low-dimensional representation of walking gait, which they can then use to compare "gait signatures" across individuals. This approach helps circumvent the issue that it is often tough to interpret differences in joint kinematics without an underlying model, but full biomechanical models are typically too intense.
Although it was only applied to humans in this preprint, I expect this approach will also be useful for those of us perturbing the nervous systems of flies/mice/monkeys/etc and trying to identify subtle and often confusing changes in body pose/joint kinematics.
My only criticism is that it needs a decent acronym. Best I came up with is U DISGUST ME (Unsupervised Discovery of Individual Stereotyped Gait Uniqueness Signatures To Manifold Everyone)