The neocortical infrastructure for language involves region-specific patterns of laminar gene expression. New paper by Maggie Wong et al. magsmaggiewong et al. @ProfSimonFisher @clydefrancks https://doi.org/10.1073/pnas.2401687121

For those interested in #asymmetry, this recent paper using Delphi method to try and reach consensus on assessment of #laterality is worth a read:
https://www.tandfonline.com/doi/full/10.1080/1357650X.2023.2199963
#neuropsychology

New study: We examined whether left-handedness🤚is associated with rare, protein-altering genetic variants, using exome sequence data from 38,043 left-handed and 313,271 right-handed individuals from the UK Biobank. More evidence for the involvement of microtubules and genes linked to psychiatric traits: https://biorxiv.org/content/10.1101/2023.05.31.543042v1

For people interested in brains, psychiatry and language: Our new consortium study of brain asymmetry in schizophrenia is out now: https://www.pnas.org/doi/10.1073/pnas.2213880120 5,080 affected and 6,015 unaffected people from 46 datasets from many countries. Findings include slightly reduced asymmetry of middle temporal cortical thickness in affected people, which might be consistent with altered organization of language functions

Our study on the genetics of human brain wiring in more than 30,000 people from UK Biobank is published now in Science Advances https://science.org/doi/10.1126/sciadv.add2870
It includes mapping of how polygenic dispositions to various brain disorders or left-handedness relate to white matter connectivity in the brain. Also specific genetic effects on connections within the left-hemisphere language network

Interesting study of functional #laterality in developing brains of fetuses in utero: 'connectivity in ... regions corresponding to Wernicke’s area was significantly left-lateralized' https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhac446/6908756

Genetic architecture of brain age and its causal relations with brain and mental disorders https://www.medrxiv.org/content/10.1101/2023.01.09.23284310v2

A first for me - Tokyo! Heading to Kobe on Monday

RT @abenitezburraco@twitter.com

Nine levels of explanation for understanding the causes of behavior
https://link.springer.com/article/10.1007/s12110-021-09414-8

🐦🔗: https://twitter.com/abenitezburraco/status/1613585486840303627

RT @doctorveera@twitter.com

Better late than never. Happy and relieved to share a final published version of one of my PhD projects in which we uncovered a fascinating genetic link between language ability, psychiatric risk and creativity. 🧵
https://www.nature.com/articles/s41598-022-26845-0

🐦🔗: https://twitter.com/doctorveera/status/1612624930256060416

“We don’t know what society and the economy will need next year or in 10 years,” ERC President @mLeptin argues for giving researchers the freedom and resources to dig into fundamental questions that may have no immediate utilitarian output.

@IrishTimes https://www.irishtimes.com/science/2022/12/22/on-bolstering-blue-sky-research-now-to-solve-future-problems/

🐦🔗: https://n.respublicae.eu/ERC_Research/status/1605907730832711680

Seems like good news for those of us trying to measure brain connections in big data sets: Choice of parcellation atlas might not be too critical for connectomic analysis https://www.biorxiv.org/content/10.1101/2022.12.20.521276v1

RT @NeuroecologyLab@twitter.com

We will be recruiting a post-doc working on machine learning approaches to compare mouse and human brain organization @OxfordWIN@twitter.com soon. The time scale is short, so if you're interested, please get in touch! (Plz RT)

🐦🔗: https://twitter.com/NeuroecologyLab/status/1603402791074103302

RT @cedricboeckx@twitter.com

“Atypical #language network #lateralization is reflected throughout the macroscale functional organization of #cortex” Nice new preprint by
@loic_lbc@twitter.com @getian107@twitter.com @bttyeo@twitter.com @AvramHolmes@twitter.com
https://www.biorxiv.org/content/10.1101/2022.12.14.520417v1

🐦🔗: https://twitter.com/cedricboeckx/status/1603348810843017217

Enjoyed talking about genetics of brain asymmetry and white matter at 'Aphasia Junior days' organized by @vipiai@twitter.com! Many of the relevant genes are most active prenatally https://www.nature.com/articles/s41562-021-01069-w - https://www.biorxiv.org/content/10.1101/2022.05.10.491289v2 Might limit scope for re-organization in post-stroke aphasia

RT @doctorveera@twitter.com

The brains of schizophrenia patients look much older than what you'd expect for their age in the MRI. Great paper showing the accelerated brain aging in schizophrenia patients across 26 cohorts.
https://www.nature.com/articles/s41380-022-01897-w

🐦🔗: https://twitter.com/doctorveera/status/1601771163176554502

RT @MPI_NL@twitter.com

There’s still time!⏰ The IMPRS for Language Sciences is offering 2 PhD Fellowships to work with scientists from @MPI_NL@twitter.com @CLSRadboud@twitter.com @DondersInst@twitter.com @Radboud_Uni@twitter.com. Choose from 7 interdisciplinary research themes. Application deadline: 2 Jan 2023. https://www.mpi.nl/imprs-phd-fellowships-2023

🐦🔗: https://twitter.com/MPI_NL/status/1599775673895178240

RT @Neuro_Skeptic@twitter.com

In praise of research in fundamental biology https://www.nature.com/articles/d41586-022-04172-8

🐦🔗: https://twitter.com/Neuro_Skeptic/status/1598356909828055041

I'm very much looking forward to give a talk about recent findings on the genetics of human brain asymmetry at the Yamada conference 'Origin of left-right asymmetry in animals' in Kobe, Japan in January https://www2.bdr.riken.jp/sympo/yamadaconference/index.html See you there @ocklenBLOG@twitter.com
! #laterality

Congratulations to Sourena Soheili-Nezhad @neurosoren@twitter.com on his PhD defence yesterday 👏- wonderful work on multivariate brain imaging genetics with @ESprooten@twitter.com , @MR_CFBeckmann@twitter.com at @DondersInst@twitter.com - and so pleased that Sourena recently joined my group at @MPI_NL@twitter.com !