Considerably more Curious than Callow.
Scientist, adventurer, father
Still missing my adopted homeland in Finland
hän/häntä
@TheBreadmonkey
Pretty ballsy claim on inflam-aging
https://www.nature.com/articles/s41586-025-09873-4
"Delivery of mRNAs encoding Delta-like ligand 1 (DLL1), FLT3L and IL-7 to hepatocytes expanded common lymphoid progenitors, boosted de novo thymopoiesis without affecting haematopoietic stem cell (HSC) composition, and replenished T cells while enhancing dendritic cell abundance and function."
Would You Like To Save This Password
[Yes] [No] [Fuckin' Hold On Until I See It Log In Correctly]
@futurebird
If you start a conversation with the key words, "be succinct" it's a key phrase that turns off all that.
Probably the best life hack of 2025.
But yeah, I do NOT appreciate programmatic manipulation of my socially ingrained human customs.
@jon_ellis @graydon
@jguillaumes
Mmmm...
Ever wonder how 5 GLP-1 drugs hit the market within 4 months if each other?
They DO have an economic role, but it's espionage.
Now it's espionage behind the thin veneer of "our model told us" (spoilers: there is no such model)
@graydon @futurebird @cstross
@26aafa19
I shared this with a friend who works closer to the consultants and she said, "you omitted the regulatory and organizational CYA that VPs are doing by using an independent third party, no matter how much echoing they are doing."
So yes, exactly as you say, as well.
@graydon @futurebird
@futurebird
If I was being generous – and I'm not; I might attribute 'she' to the way old military engineers would talk about a prized aircraft or ship.
'she' is objectifying and creepy at best, but at least there's some historical context (however unjust) to base it on.
'He' shows insane social detachment from reality.
@robotistry @graydon
@jon_ellis
They significantly turned this praise down when they initially released gpt5. I had front row seats to a lot of peoples' fawning chatbot waifus suddenly turning into significantly more scolding (but correct) shrews.
Sometimes I like to warm my dark little heart by reading all their wounded, disappointed reviews back in August.
So yes, I agree that this was definitely by design.
@graydon @futurebird
@graydon
I was hoping that by this point non technical users would have hit the reliability wall with this tech and realized that it isn't as accurate as their smartest friend, but maybe that's not true.
I have a theory that we haven't seen the vendors attach an Alexa voice to these systems, because hearing a mistruth hits people differently than reading one.
Although it's funny to tally who the pronoun split each direction for. Almost everyone in tech uses "it" or rarely "she"
@futurebird
@graydon
I've been in the room when people decided to drop tens of millions on absolute 'brick' McKinsey consultants, just to get a voice of 'authority' in the room.
That's when I learned that even highly domain-specific VPs are desperate for the deniability that comes with consulting a third-party or Key Opinion Leader (KOL)
I think @graydon hit it on the nose with the urge to ask the oracle about every little thing.
What a shot. Seems to be real, and seems to not be a composite.
https://apod.nasa.gov/apod/ap251216.html "Explanation: What’s happening over that tree? Two very different things. On the left is the Andromeda galaxy, an object that is older than humanity and will last billions of years into the future. Andromeda (M31) is similar in size and shape to our own Milky Way Galaxy. On the right is a red sprite, a type of lightning that lasts a fraction of a second and occurs above violent thunderstorms. Red sprites were verified as real atmospheric phenomena only about 35 years ago. The tree in the center is a boab, which may live for as long as a thousand years. Boab trees grow naturally in Australia and Africa and are known for being able to store large amounts of water: up to 100,000 liters. The featured image was captured last month near Derby in Western Australia."
@DrALJONES
Sometimes I see posts where someone in the DNC will say, "Trying to keep the party together"
And uhhhhh...
Nawrh dog.
Let the assholes reveal themselves.
Let them splinter and never get elected under the same old, "if you're not voting for the party you're essentially voting against them" mechanism.
@markwoll
That's what I was gonna say.
Sounds like it's not the whole story
@georgetakei
@atax1a
Please cite me. I did and intended no such thing.
@icastico
Yeah, I think I heard a "tech-bro assumed-consent to data" subtext in the OP, unless I miss my guess
@FinalGirl
@FinalGirl
Also I'm speaking from the pov of considerably more egalitarian marriages from an EU pov.
Idk anything about the insane coercive hypercapitalism you guys have over there.
@icastico @eleanor
@FinalGirl
I said this to a married friend with 7 year old twins.
He shot back, "I think it's a lot more complicated than that. If my spouse and I were waiting for double enthusiasm we would never have sex.
It doesnt feel coercive, even if the enthusiasm is usually asymmetric."
That was 10 years ago and now I have a kid of my own.
Asymmetric enthusiasm is not even close to coercion.
@icastico @eleanor
@burnoutqueen
It's funny because before the holiday break I was sitting in a room full of many of the world's best computational biologists, digging through all the genetic, biochemical, and environmental data that one of the wealthiest US biopharma companies could stuff into ML-readable data formats.
We were trying to do exactly as you said – discover a neurobiological mechanism for SCZ.
I'm curious. What is the underlying cause of SCZ that is known so well?
P.s. capitalism is killing us.
@be
This man is just an amazing photographer of the natural world!
