Autoantibody binding was verified through on-chip neutralization, revealing an overlapping motif with the commercial mAb4a 🧪 suggesting an elevated immunogenic potential of this region! (see Fig.3)

📣 Happy to share our recent research featured in Neurology "Glycine Receptor β–Targeting Autoantibodies Contribute to Autoimmune Disease Pathology" The Array fine mapped #2 GlyR Beta autoantibodies, both capable of impair glycine efficacy 🔬👨‍🔬

https://doi.org/10.1212/NXI.0000000000200187

Great work in Collaboration with the Villmann Group, spearheaded by Anna-Lena.

#RudolfVirchowCenter
#IZKF

Just had a great time at the Peptide Therapeutics Forum in Basel! 🧪💡 Shared our research on maternal Syn autoantibodies during a nice poster session. The talks, especially from non-academics, brought fresh perspective #ptf23

Fresh from the press 📰! Spearheaded by Isabel from H. Prüss' group, our article explores synapsing autoantibodies and their link to fetal abnormalities. We found a 13.3% prevalence of anti-syn in pregnant women, which was associated with neurodevelopmental disorders. Check out Figure 3, where we reveal patient-specific epitopes. 🧠🔬 #autoimmunity #peptides #synapses

https://rb.gy/w22v7

We attended an insightful and captivating talk by Christian Specht on unveiling receptor-scaffold interactions through super-resolution imaging at i-synapses. Big thanks to the Villmann lab for organizing. Rounded off the day with a delightful chat at a pizza restaurant. #SuperResolutionImaging #InhibitorySynapses #Wuerzburg @MaricLab

🎉 Exciting news from the lab! Just received the PurePep Chorus peptide synthesizer from @GyrosProteinTec. It's a game-changer! With lightning-fast speed, we can now synthesize two 15-mer peptides in under 7 hours, definitively making it the most productive dude around. Huge thanks to Luísa and Isaac for the impeccable installation, hand-on training, and post-installation assistance. #PurePepChorus #PeptideSynthesis#PNA

Thrilled to have given my first talk at the 20th edition of the #IZKF #Wuerzburg retreat! Grateful for the opportunity to share our research on immune-mediated nodopathies with the community #Mariclab

RT @ItaiYanai
Rules of academia:
Questions are more important than facts
Answers are temporary
Models are provisional
Failure happens a lot
Patience is a requirement
When you’re lucky, hopefully you realize it
Things don’t unfold linearly
If there’s free food, get there early
—Stuart Firestein

https://www.uni-wuerzburg.de/en/rvz/research/research-groups/maric-group/

Hi #Mastodon #Science #introduction 👋

I am currently working on Peptide microarray-based mapping of autoantibodies in autoimmune diseases

We aim to identify novel autoantigens targets to improve patients care in e.g. CIDP with unclear etiology

Here, our approach, by mean of the epitope knowledge, could help in explaining how these autoantibodies act on their target, thus leading to the pathology

Opening possibilities for quick/precise diagnostic tools & epitopes-specific therapies👋