See the previous #NephJC discussion in AIN from a @jci-insight.bsky.social paper here www.nephjc.com/news/cxcl9 from @mchanmd.bsky.social and Subashri Mohan #NephSky

CXCL9: A Urinary Marker ExplAI...

Previous #NephJC discussion of felzartamab in transplant ABMR here www.nephjc.com/news/felzart... from @kajareeg.bsky.social and @madihaaziz.bsky.social

Playing It Safe: Can Felzartam...

Well said #NephJC

RE: https://bsky.app/profile/did:plc:jlqwsiiirezhmxfyibrxn3nx/post/3lsgkz5ktzc2g

#nephjc Sorry can't engage more during this jc - inpatient service coupled with clinic-> came back after 12hrs. My 2c is for people to stop overthinking it and nuke CKD with the four pillars

a man in a suit and tie is poi...

But you would need a huge difference in process outcome to have a change in clinical outcomes? eg the Alerting system improved implementation but 15-20%, but not AKI outcomes: pubmed.ncbi.nlm.nih.gov/39454050/ #NephJC

Early, Individualized Recommen...

It’s a process outcome, not a clinically relevant outcome Not a bad first attempt #NephJC

Swapnil Hiremath #NephJC Flozinator, RAASinator, aspiring GLiPinator - I don’t need a nudge 😏 Haven’t read the paper, winging it with just the summary tonight!

Theories are fine - but empirical data is important to verify if the theory actually works in practice There’s a lot of fakery in this field, see @statmodeling.bsky.social statmodeling.stat.columbia.edu/2021/02/07/n... #NephJC

RE: https://bsky.app/profile/did:plc:aggc3nbjlthnoycfoogclx5m/post/3lsfdezc7sk25

Nudgelords: Given their past...

Nudging (lead by Thaler & Sunstein) has become a popular social policy intervention Like most psychology/behavioural economics though, it’s likely there’s a fakery, poor quality, and publication bias involved See onlinelibrary.wiley.com/doi/full/10.... More on #NephJC tonight!

The Effectiveness of Nudging a...

The class of 2025, #NephJC interns www.nephjc.com/news/2025/6/...

The class of 2025, #NephJC interns www.nephjc.com/news/2025/6/...

The Book Club is back Read ‘everything is tuberculosis’ from @johngreensbluesky.bsky.social with the #NephJC crew www.nephjc.com/news/2025/6/...

NephJC Bookclub returns on Aug...

Swapnil Hiremath From Ottawa Not a pediatric nephron No other CoI #NephJC

It also says that the low albumin causes edema (underfill) - need to teach the LLM that the overfill theory of primary sodium retention is more convincing #NephJC

What’s the best agent to avoid steroids in FR/SD nephrotic syndrome in children? www.nephjc.com/news/stamp Check out the #NephJC summary for this week from @brianrifkin.bsky.social with input from @jamiekwillows.bsky.social & @rheaultm.bsky.social

STAMP of Approval: Tacrolimus ...

I think @lonniepyne.bsky.social is involved in that - hope it gets published with ACHIEVE and ALCHEMIST soon - we can cover in #NephJC then! #ERA25

After covering Aprocitentan (see www.nephjc.com/news/aprocit...) @drjmluther.bsky.social moves on to Aldo synthase inhibitors This is his take on the potential role of ASIs #NephJC chat on Lorundrostat: www.nephjc.com/news/advance... #CHC25 @hypertensioncanada.bsky.social

Author in the house! Welcome to #NephJC

RE: https://bsky.app/profile/did:plc:vqxkjqrbkwuv5mghsdksuh4z/post/3lq6zdhrnoc2i

Swapnil Hiremath Nephron from Ottawa We are a site for Bax-HTN and EASiKidney No other CoI except that I will use ASI evidence to use more Spiro! #NephJC

In time for our discussion tonight! @mineralystx.bsky.social releases some data from their LAUNCH HTN trial ir.mineralystx.com/news-events/... #NephJC H/T @drwanpen.bsky.social & @drjmluther.bsky.social

Mineralys Therapeutics Announc...