Mutant Mouse Resource Research Centers is
@NIH_ORIP funded archive and distributor of #research #mousemodels.
@StanfordMed's research unveils ecDNA's role in cancer formation, intensifying the transformation of pre-cancer cells. The MMRRC's mutant mouse strains could be vital in studying ecDNA's role in cancer.
scitechdaily.com/stanford-medicine-reveals-tiny-dna-circles-defying-genetic-laws-drive-cancer-formation
👀🧬EGFR: mmrrc.org/catalog/locus_detail.php?mgi_id=MGI:95294
👀🧬MYC: mmrrc.org/catalog/locus_detail.php?mgi_id=MGI:97250
Think about all the mouse DNA that could be there too... (Scientists discover high-quality human DNA in the environment, including the air)
Lack of amino acids during development can cause long-term changes, similar to autism. How this occurs was not studied, but it leads to possible add'l studies.
genengnews.com/developmental-disorders/autism/amino-acid-deficit-impacts-perinatal-mouse-brain-development-leading-to-microcephaly-autism-behaviors
TAD boundary sequences are essential for proper genome function - or "fences" in the genome.
nature.com/articles/s42003-023-04819-w
🧬🎉Happy #DNADay! Today we celebrate the incredible discovery of the DNA structure & its impact on science!
By studying mouse DNA, we unlock the secrets to human health, unravel complex diseases & fuel medical breakthroughs! 🧬🐁
Similar to our genetic outcome analysis in mice, this article gives insight into how Medical Providers should be examining patients' genomes. What do you think?
New opportunity for cancer research: "The study shows that the EBNA1 viral protein binds to a fragile site on human chromosome 11."
🔦 Like looking at illumination at a flashlight vs. a candle, long-read sequencing tends to show more about cancer genomics and could help examine cancer in a different light. (Not to mention, 🐁 research was referenced)
scitechdaily.com/the-long-read-for-cancer-a-new-broader-genomic-view
New 🐁 studies available after machine learning 👀💻 analysis find 4 distinct autistic subtypes. Research opportunities could help with gene pathway connections and treatment options 👩
DOI: 10.1038/s41593-023-01259-x
🐁 helped us to consume more 🍟🍩🍔? Really? No, sorry. But, they did, through research at UC Irving, help discover ways to maintain energy balance and avoid obesity.
DOI: 10.1038/s41467-023-36809-1
"If you don't have gene expression, you won't have memory" - Yang K. Xiang.
(👍Hurrah for this discovery, and my gene expression for memory to tell you this study involved mouse models for the discovery🤩)
Mouse models help discover ways to prevent metastasis in escaped cells after successfully treating a primary tumor. Fantastic progression in the fight against cancer!
genengnews.com/topics/cancer/preventing-metastasis-with-a-sting
Intranasal trimeric sherpabody - a.k.a. covid protectant nasal spray can help protect against infection (tested with mouse models). Take that, spike proteins.
https://scitechdaily.com/game-changer-nasal-spray-a-universal-shield-against-all-covid-19-variants/
We've got these genes available... mmrrc.org
Can light fight cancer? With the help of #mice, researchers found a way to activate antibodies to fuse with cancer and activate with light!
https://scitechdaily.com/major-breakthrough-for-futuristic-light-activated-cancer-treatment/
Peace, well-being & happiness to you during Ramadan.
Yes, #AI and #machinelearning is all the "rage." We're a little biased regarding #mice and what it means for research.
scitechdaily.com/new-machine-learning-method-improves-our-understanding-of-cell-identity
25 interesting facts about Pi. Enjoy the day!
https://www.piday.org/pi-facts/
Quite a few new models this month. From MYBPH gene (measles & post-vaccinal encephalitis) to WDR38 (Reflex Epilepsy) with work on knocking out every gene to phenotyping them through mousepheotyping.org - we've got your mouse! mmrrc.org
Via #gene dataset analysis (which we're also good at), "Researchers uncover for the first time the mechanism that likely explains how embryos form either a larva or a miniature version of the adult." #bioinformatics