Great to see this out! EM12-SO2F engages #CRBN covalently in the IMiD pocket and can be used to efficiently block the #IMiD binding site. We share detailed methods for the synthesis and application #covalent #SuFx #histidine #TPD
Read more here: https://www.sciencedirect.com/science/article/pii/S0076687922003810?dgcid=author

Crabtree and Gray labs introduce #TCIPs! Demonstrating that chemical induced proximity between transcription factor #BCL6 and #BRD4, activates downstream #BCL6 target gene expression and results in potent apoptosis. Go go marvels of #inducedproximity! https://www.biorxiv.org/content/10.1101/2022.12.04.517548v1

Check out one of our recent webinars from Lindsey James (UNC-Chapel Hill) up now on YouTube!
"Altering the H3 methylation landscape through degradation of methyl-lysine reader proteins" https://www.youtube.com/embed/MAfXODlYDS0

Join us tomorrow for Mikko Taipale #TPDwebinar 12:00 noon EST. Register to join via zoom at https://www.danafarbertargetedproteindegradation.org/

Hello mastodon community! A brief intro: I’m a scientist in Eric Fischer’s lab and the Center for Protein Degradation at the Dana-Farber Cancer Institute excited about #targetedproteindegradation #ChemicalBiology and #InducedProximity I’m looking forward to this new experience! #Mastodon