Looks like I will have some funding to hire a computational tech for ~6 months, starting super duper soon! Can be done remotely. Looking for good computational & programming skills with a strong interest in or knowledge of systems neuroscience/hippocampus. PLS SHARE + RT!

@jonny @elduvelle yes, was basically wondering folks' thoughts on bsky vs mastodon. keeping all my accounts open for now but traffic is really picking up on bsky, and without super easy cross posting I tend to just... post on one

ok I had high hopes for mastodon but it looks like most people are migrating to bluesky instead. thoughts /concerns et al? who else is ALSO over there? i'm aheadofthenerve.bsky.social

(and some tags for the algorithm: #Neuroscience #Hippocampus #NeuralManifolds #Preprint )

7️⃣ Of course there is way more in the paper!! Feel free to hit me up with any comments/criticisms/questions! And many thanks to coauthors/mentors @SaraASolla and @DisterhoftLab, as well as @NU_BSA , the Brain Initiative k99/r00, among others

6️⃣ This discovery bridges the gap between memory and navigation research, showing how the hippocampus preserves cognitive consistency across varying spatial environments—an essential aspect of learning and memory.

5️⃣ Most surprising: this stable task representation wasn't just observed within the same animal, but also across different animals! This points to a standardized neural code or 'neural syntax' shared across individuals.

4️⃣ .... showing that task encoding in the hippocampus is resilient to context changes!

3️⃣ Advanced dimensionality reduction and machine learning techniques (shoutout to @cebraAI !!) revealed that neural manifolds representing the task maintained similar geometries across contexts (even as these same cells remapped spatially...

2️⃣ Using calcium imaging, we tracked hippocampal neuron activity as rats performed a conditioning task in multiple contexts. Despite remapping of place cells, task-related neural representations stayed consistent across environments:

1️⃣ Contextual generalization is crucial for learning and navigating the world. We focused on how the hippocampus represents task-related information across different environments, even while place cell encoding remaps.

🚨 New Preprint 🚨 Ever wondered how the HPC supports learning across different contexts? This study, w @SaraASolla & @DisterhoftLab, uncovers a 'universal' memory code in the HPC—consistent across animals and environments! 🧵👇

https://www.biorxiv.org/content/10.1101/2024.10.24.620127v1

@jonny chatgpt actually isnt terrible at this

@markgbaxter thanks, this is super helpful, i'll read them in the next few days. off the top of your head-- do individual rats switch or are there "cohorts?" I am ideally looking for a task where different rats employ different strategies (or, less ideal but still possible, you force different strategies) but individual rats don't really switch between them

@elduvelle_neuro yeah I am really looking for a task where different rats employ different strategies (or, less ideal but still possible, you force different strategies) but don't really switch between them

animal behavior / navigation folks -- do you have an example of a task where animals clearly use different strategies to solve it (ie 1/2 use an egocentric strategy 1/2 use allocentric, or some combo like that) -- and the strategies are easily identifiable? open to any thoughts/ideas!! Pls #RT :)

Zzzzz waiting for slurm scripts Zzzzzz

Who else is going to #inav ?? (#inav2024 ? #inav24 ?)

my university's high performance computing cluster is down for "upgrades" this whole week and i dont know how i will survive

fml 4ever