Postdoctoral Fellow - Pouchelon Lab

Cold Spring Harbor Laboratory

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#ScienceJobs #hiring #research
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Nick Lane presents #EMBOat60 with exciting data about chemical reactions that could explain the origin of life. This talk was a most excellent use of ten minutes of my life. Check out Nick's book "Transformer"* on this topic.

*not about Lou Reed

Wisdom from one of my scientific heros, Ottoline Leyser, at #EMBOat60 yesterday

Overly-narrow criteria for success fuel anxiety, inhibit creativity, and crush the joy out of science.

She points out that "Groundbreaking' is an analogy from the building trade.. the first step before carefully putting one brick on top of another.

If you only fund groundbreaking research then you might only end up with lots of small holes in the ground.

Research Technician I- Pouchelon Lab

Cold Spring Harbor Laboratory

See the full job description on jobRxiv: https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-research-technician-i-pouchelon-lab-2/?feed_id=85408

#ScienceJobs #hiring #research
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Thank you to the organizers of the ‘Developmental Specification of Complex Behaviors’ conference at #JaneliaResearch for the opportunity to present our work. It was a fantastic meeting, and we had great discussions on the latest insights into developmental neurobiology! #NewsMayerlab

I had a great time traveling to the US this week to present our research at the #CSHL (Cold Spring Harbor Laboratory) neuro seminar series. Thanks to my hosts for a great visit. #NewsMayerlab

Taking some time to enjoy the #Oktoberfest with the team! A great chance to unwind and celebrate together. Prost to good company, and great teamwork! 🍻 #LabLife #NewsMayerlab

🥳 Officially released today: 🎉

New version of the VISTA ENHANCER BROWSER, with expanded support for developmental timepoints and comparisons of disease and evolutionary alleles of enhancers

Let us know what you think!

https://enhancer.lbl.gov/

New study "Multiple parallel cell lineages in the developing mammalian cerebral cortex" led by Lucia Del-Valle-Anton and the @Borrell_Lab (Alicante) is published. Great collaboration with the labs of Juan Antonio Moreno-Bravo (Alicante) and Magdalena Götz (Munich). Congrats to our lab members Florian Neuhaus, @Elena_dvoretskova, Yigit Babal, Chao Feng for their contribution! Link: https://www.science.org/doi/10.1126/sciadv.adn9998 @MPIforBI #NewsMayerlab"

Thanks to a fantastic team for making this work possible, especially @Elena_dvoretskova, May Ho, Volker Kittke Volker. @ERC_Research for funding! @MPIforBI for support in the establishment of our research group. 7/7

Enhancers that drive projection neuron-specific gene expression are accessible in all parts of the GE (ATAC-seq Rhodes et al). Yet, their activity is restricted to the LGE. Thus, "differential TF binding" rather than "differential accessibility" induces projection neuron fate 6/7

We conducted ChIP-seq and luciferase reporter assays and found that MEIS2 requires the presence of DLX to direct its functional activity towards regulatory elements of projection neuron genes containing specific DLX/MEIS co-binding sites. 5/7

By combining tCROPseq CRISPR perturbation sequencing and barcode lineage tracing (TrackerSeq) in vivo, we provide further evidence that MEIS2 perturbation results in a fate switch from LGE projection neurons to interneurons. 4/7

We developed a transposon-based version of CROP-seq (tCROP-seq) with improved in vivo efficiency. Its application confirmed our hypothesis: MEIS2 removal decreased the proportion of projection neurons and increased the proportion of interneurons, suggesting a fate switch. 3/7

In Bandler et al. we showed that in the GE single cell trajectories of projection and interneurons diverge from a common pool of mitotic progenitors (https://doi.org/10.1016/j.conb.2023.102691). We now show that MEIS2 expression is the strongest predictor of projection neuron fate. 2/7

Excited to announce that our study "Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development" is now online in Nature Neuroscience https://www.nature.com/articles/s41593-024-01611-9 Big thanks to the Winkelmann (#Helmholz @tu_muenchen & Torres (#CNIC_CARDIO) labs for the collaboration! #NewsMayerlab. See the thread to find out more: 1/7

Unsere aktuellste Arbeit wurde auf der Website des Max-Planck-Instituts für Biologische Intelligenz präsentiert! Schauen Sie sich den Artikel an, um mehr zu erfahren: https://www.bi.mpg.de/news/2024-03-mayer/de #Wissenschaft #Neurowissenschaften #Forschung #NewsMayerlab

Our most recent work has been featured on the MPI Biological Intelligence website! Check out the article to learn more: https://www.bi.mpg.de/news/2024-03-mayer #Science #Neuroscience #Research #NewsMayerlab

How does the competence of GABAergic progenitors change in time? Well, it depends on whether you're looking at maturation or differentiation! Check out our new preprint on #BioRxiv: https://doi.org/10.1101/2024.03.18.585524
Big shoutout to the amazing contributors, Yana, Ann, Flo, Ilaria and our collaborators Diana Rodrigues and Mike Myoga! #NewsMayerlab

@eLife