Lmst

Hanon McShea

Graduate student working on evolution of proteins and biological membranes at Stanford University.

Interested in #evolution, #MolecularEvolution, #ProteinEvolution, #lipids, #membranes, #bacteria, and #archaea

Hanon McShea boosted:

Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper

Hanon McShea boosted:

Our latest #preprint develops a new metric of #CodonAdaptation (not just #CodonBias) to measure the kind of #EffectivePopulationSize that matters to #NearlyNeutralTheory, and uses it to discover that #NaturalSelection prefers high #IntrinsicStructuralDisorder https://www.biorxiv.org/content/10.1101/2023.03.02.530449v1 1/6
#MolecularEvolution #PopulationGenetics #EvolgenPaper

Hi mastodon,

Last chance to submit an abstract to the Protein Evolution symposium that Georg Hochberg and I are organizing at #SMBE23 #SMBE2023 in Ferrara, Italy!

@JoannaMasel and Patrick Shih will be speaking.

Abstracts are due tomorrow March 15th at https://www.smbe2023.org/

Join us! :)

CALL FOR ABSTRACTS

Causation in Protein Evolution Symposium at the Society for Molecular Biology and Evolution 2023 Conference. July 23-27 in Ferrara, Italy with invited talks from Joanna Masel and Patrick Shih.

In the light of evolution, what gives rise to observable properties of proteins, such as marginal stability of folding, catalytic rate enhancement, amino acid composition, and multimeric status? How do physical and physiological realities such as temperature, mutation bias, and crowded nature of cellular environments affect the outcomes of protein evolution that we observe? Causal questions arise in a variety of evolutionary contexts, including but not limited to de novo protein emergence, adaptation to extreme environments, long-term trends, and the degrees to which protein evolution is neutral, nearly neutral, and adaptive. From a biochemistry perspective, the advent of high- throughput techniques provides the means to test the mechanistic basis of evolutionary theories. These include multiplexed measurements of thermodynamic, kinetic, and fitness effects of mutations and natural variation in proteins, as well as high-throughput prediction of protein structures, for example Alphafold. This symposium aims facilitate interaction between evolutionary biologists and biochemists working on evolutionary problems.

Please submit abstracts at tinyurl.com/proteinevol We welcome abstracts from all protein evolution enthusiasts.

Hello mastodon! A late introduction. I'm a grad student studying the evolution of proteins involved in lipid membrane biosynthesis. Also interested in dynamics of protein evolution in general, and weird membrane biophysics and physiology outside of the human/bacillus/escherichia canon.

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