ScienceAlert: Cutting Back on Isoleucine an Amino Acid Increased Lifespan in Middle-Aged Mice Up to 33%

https://www.sciencealert.com/cutting-back-on-one-amino-acid-increased-lifespan-in-middle-aged-mice-up-to-33

#isoleucine

In experiments with mice, researchers found that restricting the intake of a particular amino acid, called isoleucine, can increase the lifespan of middle-aged mice by up to a third. Isoleucine is found in eggs, soy, and meat. See http://www.neat-news.com/2024/12/302.php. #diet #lifespan #isoleucine

Isoleucine

ScienceAlert: Cutting Back on One Amino Acid Increases Lifespan of Mice Up to 33%
https://www.sciencealert.com/cutting-back-on-one-amino-acid-increases-lifespan-of-mice-up-to-33

#thisonething #isoleucine

The Isoleucine Paradox: Eat More, Weigh Less, Live Longer
https://scitechdaily.com/the-isoleucine-paradox-eat-more-weigh-less-live-longer/ #Aging #Diet #Longevity #Metabolism #Isoleucine #AminoAcids #mice

Amino Acid....too much or too little?

#Isoleucine

https://www.sciencealert.com/cutting-back-on-one-amino-acid-increases-lifespan-of-middle-aged-mice-up-to-33

"Mice eating less of specific amino acid — overrepresented in diet of obese people — live longer, healthier"

From the article:

"Isoleucine is plentiful in foods including eggs, dairy, soy protein and many kinds of meat."

😱 OMG! We have to stop eating eggs, dairy, soy protein, and many kinds of meat.

We have a special diet just for this!

Also, from the article:

"'We can’t just switch everyone to a low-isoleucine diet,' Lamming says."

🤔 Watch us confuse correlation and causation, put our fingers in our ears, and ignore this inconvenient comment.

#USNews #isoleucine #diet #WeightLoss #CorrelationIsNotCausation #correlation #causation #SnakeOilSalesmen

https://news.wisc.edu/mice-eating-less-of-specific-amino-acid-overrepresented-in-diet-of-obese-people-live-longer-healthier/

Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper