reactome

Reactome is an open source curated pathway database that provides pathway and network analysis tools for life science researchers.

reactomereactome
2025-04-02

⚠️ In our next version (v93) of Reactome, we will be migrating our Docker image hosting from DockerHub to AWS Elastic Container Registry (ECR). Users will be able to pull our container images from AWS ECR. Please reach out to help@reactome.org if you have any questions.

reactomereactome
2025-04-02

A sincere thank you to our external contributors, who provide valuable feedback and review for our pathways. If you are interested in contributing, check out how you can do so, at this link: reactome.org/community

reactomereactome
2025-04-02

Release News: V92 of is live! 🎉

We have exciting new and updated topics and pathways in this release. This release, we added 81 new reactions to Reactome, which you can read about at this link: reactome.org/about/news/270-v9

reactomereactome
2025-02-14

Discover Pathways with Ease!
Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire.

Link: reactome.org/chat/

reactomereactome
2025-02-04

Check out the Reactome Research Spotlight 💡 for February 2025. The paper "BPP: Biochemical Pathway Prediction framework" by Yi et al is summarized here: reactome.org/content/reactome-

If you have a publication that leverages Reactome, please submit them to help@reactome.org for our team's consideration for next month!

reactomereactome
2025-01-13

The
for January is a paper by Tindle et al. that identified two Crohn’s disease (CD) molecular subtypes - immune-deficient infectious CD and stress and senescence-induced fibrostenotic CD - through multi-omics and functional analyses of patient-derived organoids.

Read more here! reactome.org/content/reactome-

reactomereactome
2024-12-19

Release News: V91 of is live! 🥂 🎉

We have exciting new and updated topics and pathways in this release, including Cellular responses to stimuli, Developmental Biology, DNA Replication, Extracellular matrix organization, Immune system, and Signal transduction. This release, we added 99 new reactions to Reactome, which you can read about at this link: reactome.org/about/news/265-v9

reactome boosted:
Egon Willighagenegonw@social.edu.nl
2024-12-19

the Serious Request fundraiser is nearing. The DJs lock themselves up in just under two weeks and on the 16th I start a week long working on metabolic disease related pathways, joined by already three others: sr24.wikipathways.org/

But the preparation has already started. I have spoken with researchers from @reactome, our TGX group doing research on mitochondria, and researchers in our university hospital.

Your donation to our action for the MetaKids foundation is welcome!

#sr24 #metakids

Screenshot of our (linked) Serious Request "Kom in Action" landing page, showing our plans, including the new list (and at the bottom four existing pathways): 

 Welcome to the Serious Request 2024 - MetaKids page.

The Serious Request 2024 action is to raise funding for MetaKids, a Dutch foundation that aims for a world in which metabolic diseases can be treated or prevented and where no kid has to suffers from these diseases.

This WikiPathways actions aims to raise funding for the Serious Request 2024 action and in return we will work in December on improving the digitalized versions of the latest literature about the biological process that are behind or could perhaps explain these metabolic diseases.

This page lists the pathways we worked on during the action or are otherwise relevant to the work by the MetaKids foundation. We further have this project board to monitor the specific tasks, in an open notebook science sense. Also, a dedicated curation website is maintained.

See also the "WikiPathways in actie voor MetaKids" page where you can donate money for MetaKids.

Pathways planned to work on

- Pathways directly linked to diseases currently mentioned in research articles by United for Metabolic Diseases, e.g. WP4156
- Pathways describing mitochondrial processes
- Pathways not digitized in the book behind the IMD portal, see this table

Contact

Egon Willighagen and Martina Summer-Kutmon .
reactomereactome
2024-11-26

Do you know about ALL the ways you can download Reactome?

Check out our latest youtube video created by Cristoffer Sevilla describing our downloadable materials!

Don't forget to share and like our video:
youtu.be/UJfPfWpq9lA

reactome boosted:
reactomereactome
2024-11-12

Let's play 20 questions!

If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: docs.google.com/forms/d/e/1FAI

reactomereactome
2024-11-01

Let's play 20 questions!

If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: docs.google.com/forms/d/e/1FAI

reactomereactome
2024-10-15

ReactomeResearchSpotlight is updated monthly on our website's homepage! Our staff selects candidate articles to feature. After team discussion, the winner is posted on our home page.

Contact us at help@reactome.org with if you want to be featured as the next Spotlight!

reactomereactome
2024-10-15

The Target2035 mission is to discover chemical tools for all human proteins by 2035. An ambitious and impactful mission!

The authors use Reactome as the reference standard to determine the chemical coverage of human biological pathways and to outline the advantages of adopting the pathway-based rather than the proteome-based approach in guiding Target 2035 efforts.

reactomereactome
2024-10-15

An exciting ReactomeResearchSpotlight!
In the feature article of the October 2024 issue of Drug Discovery Today titled "Chemical coverage of human biological pathways" by Kwak et al. describe the Target2035 initiative!

Read more: reactome.org/content/reactome-

reactomereactome
2024-10-03

Release News: V90 of is live! 🥂 🎉

We have new and updated topics and pathways in this release, including Cellular response to stimuli, Disease, Gene Expression, Metabolism, and Metabolism of Proteins, which you can read about at this link: reactome.org/about/news/261-v9

Big shoutout to our contributors! If you are interested in contributing, check out how you can do so, at this link: reactome.org/community

reactomereactome
2024-09-23

We were thrilled to collaborate with
Biobox Analytics on an article exploring
Reactome’s curation practices and our innovative graph database! Check it out!

blog.biobox.io/p/the-reactome-

reactomereactome
2024-09-17

Time for ! Bracha et al. use expression analysis to confirm that they successfully delivered multiple large therapeutic proteins across the blood-brain barrier into target neurons in mice using engineered Toxoplasma gondii secretion systems.

See full article here: ncbi.nlm.nih.gov/pmc/articles/

See our website for more exemplary research done using Reactome!
reactome.org/content/reactome-

Contact us with your amazing work to be considered for next month's spotlight!

reactomereactome
2024-09-10

Going to#ASHG2024🏔?

Reactome is coming to Denver, CO! Come talk to Nancy Li in the session about the knowledgebase, and how you can use our data and analysis tools in your research!

Please reach out if you'd like to chat!

reactomereactome
2024-07-31

Need a ~3 minute intro to 's analysis tools?

Check out our latest youtube video created by Cristoffer Sevilla describing our qualitative and quantitative data analysis methods!

Don't forget to share and like our video: youtu.be/rxEpA-lJguE?si=mK2tmJ

reactome boosted:
Gene Ontologygo@genomic.social
2024-07-25

Cancer research progresses every day. In a new paper from Huang et al, there is a novel prognostic signature that may help predict immunotherapy response- and they use GO to help their research:

community.alliancegenome.org/t

Client Info

Server: https://mastodon.social
Version: 2025.04
Repository: https://github.com/cyevgeniy/lmst