⚠️ In our next version (v93) of Reactome, we will be migrating our Docker image hosting from DockerHub to AWS Elastic Container Registry (ECR). Users will be able to pull our container images from AWS ECR. Please reach out to help@reactome.org if you have any questions.

A sincere thank you to our external contributors, who provide valuable feedback and review for our pathways. If you are interested in contributing, check out how you can do so, at this link: reactome.org/community

Release News: V92 of #Reactome is live! 🎉

We have exciting new and updated topics and pathways in this release. This release, we added 81 new reactions to Reactome, which you can read about at this link: https://reactome.org/about/news/270-v92-news

Discover Pathways with Ease!
Explore biological pathways like never before with the React-to-Me AI Chatbot. We’d love your feedback to improve it! Try it now and share your experience through our short questionnaire.

Link: https://reactome.org/chat/

Check out the Reactome Research Spotlight 💡 for February 2025. The paper "BPP: Biochemical Pathway Prediction framework" by Yi et al is summarized here: https://reactome.org/content/reactome-research-spotlight/267-bpp-a-platform-for-automatic-biochemical-pathway-prediction

If you have a publication that leverages Reactome, please submit them to help@reactome.org for our team's consideration for next month!

The #ReactomeResearchSpotlight
for January is a paper by Tindle et al. that identified two Crohn’s disease (CD) molecular subtypes - immune-deficient infectious CD and stress and senescence-induced fibrostenotic CD - through multi-omics and functional analyses of patient-derived organoids.

Read more here! https://reactome.org/content/reactome-research-spotlight/266-a-living-organoid-biobank-of-patients-with-crohn-s-disease-reveals-molecular-subtypes-for-personalized-therapeutics

Release News: V91 of #Reactome is live! 🥂 🎉

We have exciting new and updated topics and pathways in this release, including Cellular responses to stimuli, Developmental Biology, DNA Replication, Extracellular matrix organization, Immune system, and Signal transduction. This release, we added 99 new reactions to Reactome, which you can read about at this link: https://reactome.org/about/news/265-v91-news

the Serious Request fundraiser is nearing. The DJs lock themselves up in just under two weeks and on the 16th I start a week long working on metabolic disease related pathways, joined by already three others: https://sr24.wikipathways.org/

But the preparation has already started. I have spoken with researchers from @reactome, our TGX group doing research on mitochondria, and researchers in our university hospital.

Your donation to our action for the MetaKids foundation is welcome!

#sr24 #metakids

Do you know about ALL the ways you can download Reactome?

Check out our latest youtube video created by Cristoffer Sevilla describing our downloadable materials!

Don't forget to share and like our video:
https://youtu.be/UJfPfWpq9lA

Let's play 20 questions!

If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: https://docs.google.com/forms/d/e/1FAIpQLSdgKOPoGm3nDHckrdJb9D0Gg5JJOEFkfp0jZE3DXsC6hcPzUg/viewform
#openscience #pathway #biology

Let's play 20 questions!

If Reactome has touched your work or helped you save valuable time, please consider giving us 5 minutes of your time through our user survey, reachable at our home page, or at the following link: https://docs.google.com/forms/d/e/1FAIpQLSdgKOPoGm3nDHckrdJb9D0Gg5JJOEFkfp0jZE3DXsC6hcPzUg/viewform
#openscience #pathway #biology

ReactomeResearchSpotlight is updated monthly on our website's homepage! Our staff selects candidate articles to feature. After team discussion, the winner is posted on our home page.

Contact us at help@reactome.org with if you want to be featured as the next Spotlight!

The Target2035 mission is to discover chemical tools for all human proteins by 2035. An ambitious and impactful mission!

The authors use Reactome as the reference standard to determine the chemical coverage of human biological pathways and to outline the advantages of adopting the pathway-based rather than the proteome-based approach in guiding Target 2035 efforts.

An exciting ReactomeResearchSpotlight!
In the feature article of the October 2024 issue of Drug Discovery Today titled "Chemical coverage of human biological pathways" by Kwak et al. describe the Target2035 initiative!

Read more: https://reactome.org/content/reactome-research-spotlight/262-chemical-coverage-of-human-biological-pathways

Release News: V90 of #Reactome is live! 🥂 🎉

We have new and updated topics and pathways in this release, including Cellular response to stimuli, Disease, Gene Expression, Metabolism, and Metabolism of Proteins, which you can read about at this link: https://reactome.org/about/news/261-v90-news

Big shoutout to our contributors! If you are interested in contributing, check out how you can do so, at this link: https://reactome.org/community

We were thrilled to collaborate with
Biobox Analytics on an article exploring
Reactome’s curation practices and our innovative graph database! Check it out!

https://blog.biobox.io/p/the-reactome-knowledgebase-powering?r=7527y&utm_campaign=post&utm_medium=web&triedRedirect=true

Time for #ReactomeResearchSpotlight! Bracha et al. use #Reactome expression analysis to confirm that they successfully delivered multiple large therapeutic proteins across the blood-brain barrier into target neurons in mice using engineered Toxoplasma gondii secretion systems.

See full article here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11306108/

See our website for more exemplary research done using Reactome!
https://reactome.org/content/reactome-research-spotlight

Contact us with your amazing work to be considered for next month's spotlight!

Going to#ASHG2024🏔?

Reactome is coming to Denver, CO! Come talk to Nancy Li in the #OmicsTechnology session about the #Reactome knowledgebase, and how you can use our data and analysis tools in your research!

Please reach out if you'd like to chat!

Need a ~3 minute intro to #Reactome's analysis tools?

Check out our latest youtube video created by Cristoffer Sevilla describing our qualitative and quantitative data analysis methods!

Don't forget to share and like our video: https://youtu.be/rxEpA-lJguE?si=mK2tmJU4ICXlGqiN

Cancer research progresses every day. In a new paper from Huang et al, there is a novel prognostic signature that may help predict immunotherapy response- and they use GO to help their research:

https://community.alliancegenome.org/t/go-and-lung-adenocarcinoma/7746