During corticogenesis, progenitor competence changes over time — generating distinct excitatory neuron types.

But it turns out that in inhibitory lineages, progenitors retain stable differentiation competence. Instead, temporal progression alters maturation dynamics.

#NewsMayerlab #Corticogenesis #PatchClamp

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Arl2 regulates asymmetric division in fly neural stem cells via control of #microtubule growth. @HongyanWang9 &co show that, in mammalian #cortex, Arl2 binds to Cdk5rap2 to control microtubule growth, so regulating #corticogenesis #PLOSBiology https://plos.io/4dqDo5q