Crystal structures of a clinically used histone deacetylase inhibitor, vorinostat, bound to the previously unidentified off-target proteins carbonic anhydrases II and IX are reported #HDACInhibitors #SAHA #Vorinostat https://doi.org/10.1107/S2053230X25007447

A newly discovered gene may explain why some prostate cancers become deadly — and how we might stop them. #ProstateCancer #GeneTherapy #HDACinhibitors

https://geekoo.news/the-hidden-gene-driving-prostate-cancers-dark-turn/