A role for #HistoneMethylation in metabolic regulation? #Histone methyltransferases are co-regulated by #TumorSuppressor Rb; altered expression controlled by Rb leads to reorganization of S-adenosyl methionine metabolism @PSarkies #PLOSBiology https://plos.io/3MhUfM4

Lacramioara Bintu of Stanford
https://bintulab.com/

#SingleCell dynamics of gene silencing, epigenetic memory, and #chromatin organization

silencing & reactivation of expression all-or-none via #histonemethylation

3 states: active, reversible silent, irreversible silent

chromatin regulators move proportion of cells in OFF state

KRAB can "remember" duration of signal, makes heterochromatin, which can spread spatially

Want to see chromatin state in single cells

#CSSinglecells23

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