Lmst

#LUBAC

Vote for de Lubac beatification raises Jesuit influence in modern-day Church

Last week the #French bishops voted in favor of opening a beatification cause for the late Cardinal Henri de #Lubac, a celebrated theologian whose writings influenced not only the Second #Vatican Council, but every pope since.

https://cruxnow.com/church-in-europe/2023/04/vote-for-lubac-beatification-raises-jesuit-influence-in-modern-day-church

Final issue of our 40th #anniversary year!

Featured:
#LUBAC linear #ubiquitin signaling on #mitochondria
#Calnexin’s sugar-free taste in #lipid #bilayer
#Mitophagy receptors doubling in #pexophagy
#Cadherin-mediated #adhesion control (on the cover by Liang, Buckley et al)

...and more:
https://www.embopress.org/toc/14602075/2022/41/24

This cover highlights the article E‐cadherin mediates apical membrane initiation site localisation during de novo polarisation of epithelial cavities by Xuan Liang, Clare E Buckley and colleagues. During epithelial polarisation of embryonic stem cells, the site of apical membrane initiation is defined by E‐cadherin mediated cell adhesion independently of cell division. Image shows chimeric cell doublets and epithelial cysts labelled with E‐cadherin in Magenta, F‐actin in blue and PAR‐3 in green. Only doublets with E‐cadherin in both cells form a PAR‐3 positive AMIS. Whilst epithelial cysts expressing E‐cadherin formed lumens via hollowing, those without E‐cadherin formed lumens via folding.

"In mice, the loss of Sharpin leads to severe dermatitis due to excessive cell death in keratinocytes. Here we report the first patient with SHARPIN deficiency, manifesting fever, arthritis, colitis, chronic otitis media and hepatic glycogenosis but unexpectedly, not associated with dermatologic manifestations."

#Immunology #HumanGenetics #Immunedeficiency #LUBAC #Sharpin

https://www.medrxiv.org/content/10.1101/2022.11.09.22281431v1