New review out: "Metabolic Modeling of Host–Microbe Interactions". In the article, we:
Outline strategies for coupling host and microbial genome scale metabolic models #GEM
Highlight successful applications revealing #HostMicrobiome cross-feeding
Discuss challenges (regulation, dynamics, model validation) and possible solutions
Outline fields which are worthwhile exploring from a #SystemsBiology perspective

https://doi.org/10.1016/j.csbj.2025.10.006

#MetabolicModeling #MicrobiomeScience #ComputationalBiology

We are looking for a #PhD student who applies #MetabolicModeling to explore metabolic #hostMicrobeInteraction in the #gutBrainAxis for #coginitiveDecline during #menopause. A special focus will be laid on the role of the #microbiome in the production/degradation of hormones and the consequences on the brain. Please share and recommend!

More infos here:
https://bsky.app/profile/kaletalab.bsky.social/post/3m2qlozorvs27

Ad for the vacancy is here:
https://www.uniklinikum-jena.de/menobrain/en/Recruitment+_+Open+Calls/DC+8+_+UKSH-p-42.html

Our (@kaletalab) new study uncovers multi-level metabolic disruptions in #IBD involving reduced #HostMicrobiomeInteractions.

Elevated tryptophan catabolism → NAD biosynthesis impaired.

Disrupted nitrogen homeostasis affects polyamine/glutathione metabolism.

Suppressed C1 cycle alters NAD/phospholipid profiles.

#MetabolicModeling predicts dietary interventions to restore #Microbiome balance.

Read and share: https://rdcu.be/eo7B3
#SystemsBiology #Microbiome #MultiOmics #CAU #UKSH #Kiel