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#MitochondrialDynamics

PLOS BiologyPLOSBiology@fediscience.org
2025-10-23

#MitochondrialDynamics are important regulators of various cancer cell phenotypes. This Essay explores the role of mitochondrial dynamic regulators in #tumor growth & #metastasis, discussing how they can be targeted to develop novel intervention strategies
@PLOSBiology plos.io/4o4KtOo

Mitochondrial division and fusion control mitochondrial structure. Top: Mitochondrial division, mediated by DRP1, decreases mitochondrial size and increases their number. Mitochondrial fusion, controlled by MFNs and OPA1, counteracts division to maintain mitochondrial integrity. Mitochondrial degradation by mitophagy is influenced by mitochondrial size. Bottom: Parkin and OMA1 negatively regulate mitochondrial fusion. Parkin is activated by phosphorylation mediated by the kinase PINK1. Activated Parkin ubiquitinates MFN1, leading to its degradation. OMA1 regulates mitochondrial fusion by cleaving OPA1.DRP1, dynamin-related protein 1; FIS1, fission protein 1; MFF, mitochondrial fission factor; MFN, mitofusin; MID49/51, mitochondrial dynamics proteins of 49 and 51 kDa; MITOK/CCDC51, mitochondrial ATP-sensitive potassium channel/coiled-coil domain-containing protein 51; OMA1, OMA1 zinc metallopeptidase; OPA1, optic atrophy 1; PINK1, PTEN induced kinase 1. Created in BioRender.

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