Trailmakers 2.0: Pioneers🏍️🛠️ PrePlay [4K | 2025]

https://youtu.be/l4zTuvhvqUg?si=6Ec8uc8kzGsBOkql

#gaming #games #test #gameplay #RocketFaultier #SpaceFaultier #PrePlay

@adredish

So it looks like rats only run one way in this task, right (say, A -> B)*? So you wouldn't be able to sample place cell activity in the other direction (B->A) and I don't see directional place fields mentioned in the paper.

But reverse replay is supposed to be a reactivation of the place cells in the reverse order that they are experienced (i.e., rat "running backwards", not running forward in the other direction) which can only be tested if the place cells are directional...

(e.g. as in Reverse replay of behavioural sequences in hippocampal place cells during the awake state:

"A number of cells were bidirectional, in that they did not have a peak firing rate in a preferred direction that was at least double that in the opposite direction (52% bidirectional neurons in the new sessions; 35% in the familiar sessions), raising the possibility that apparently reverse replay events merely reflected forward replay of neurons in the opposite direction"

when then remove the bidirectional cells, they still find a significant number of reverse replay events)

So perhaps the 'backward' replay is reverse replay, but it could also be forward replay in the other direction.

That being said, bidirectional cells probably contribute to both types of events, but I am not sure that we can call a replay "reverse" if we don't have directional cells contributing to it. 🤔

And also, just to complicate things even more, in the case of your task the rat has not experienced the other direction (B -> A) so wouldn't replay of that be... #preplay ?? 😅

(* I know that technically this task is a circle so it's really A-> A but that doesn't help the explanations)

Potentially very interesting #NeuroPaper in #Humans:
Backbone spiking sequence as a basis for preplay, replay, and default states in human cortex

(Thanks to my colleague Hung-Tu for highlighting this one!)

(I’m not sure we can really say that preplay has been “robustly demonstrated” in rodents though…)

#Replay #Preplay #AnteriorTemporalLobe #MicroElectrodeArray #NeuroHuman