Two structures of Legionella pneumophila serogroup 1 peptide deformylase (PDF) provide insight into PDF inhibition and support continued anti-PDF drug-development efforts #SSGCID #StructuralGenomics #>PeptideDeformylases https://doi.org/10.1107/S2053230X25001876

Apo and dUMP-bound structures of Legionella pneumophila dUTPase revealed a potential new binding site and active-site structural differences when compared with human dUTPase #SSGCID #StructuralGenomics https://doi.org/10.1107/S2053230X25001815

Differences in the binding pocket provide insight for the development of selective inhibitors that target bacterial TrpRS without interfering with the human cytosolic form #StructuralGenomics #NeisseriaGonorrhoeae #TryptophanylTRNASynthetase https://doi.org/10.1107/S2053230X25001311

Two structures of Brucella ovis leucine-, isoleucine-, valine-, threonine- and alanine-binding protein are reported that show its conformational flexibility in the absence of bound amino acids
#SSGCID #StructuralGenomics #Brucellosis https://t.co/aDI9PPMCdu

Three crystal structures of two NAD(P)H nitroreductases from Klebsiella pneumoniae are presented and an analysis of their structures and their flavin mononucleotide-binding mode is provided. #Nitroreductase #SSGCID #StructuralGenomics https://t.co/0dFO1nRWzB

New Section Editor @glycojones comments on the involvement of undergraduate students in a recent @ActaCrystF paper and encourages submissions from young researchers @iucr #StructuralGenomics #InorganicPyrophosphatases #Legionella https://doi.org/10.1107/S2053230X2300883X

The crystal structure of a family I inorganic pyrophosphatase from L. pneumophila was solved as part of structural genomic studies at SSGCID and demonstrated the expected enzymatic activity #StructuralGenomics #InorganicPyrophosphatases #Legionella https://doi.org/10.1107/S2053230X23008002