#SurrogateEndpoints

Wolfgang Viechtbauerwviechtb@scholar.social
2025-03-19

Another new paper alert. We just published a paper giving a likelihood-based implementation of the Daniels & Hughes bivariate meta-analysis model for surrogate endpoint evaluations (e.g., using progression-free survival as a surrogate for overall survival): doi.org/10.1002/bimj.70048

We propose a bias-adjusted MLE for the variance component of the model, present simulation results, and illustrate the method with a few case studies.

#Statistics #SurrogateEndpoints #MetaAnalysis

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