TGF-β1 Transactivates ADAMTS-2 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif 2) in Saos-2 Cells through Canonical and Non-Canonical Pathways - #ADAMTS2 #TGFβ1 #osteosarcoma #Saos2 #transcriptionalregulation - https://link.springer.com/article/10.3103/S0095452723030027

Happy to collaborate on this study profiling the existence and development of cross-tissue #ILC1 in humans.

https://doi.org/10.1016/j.celrep.2022.111937

Key Takeaways:

-Human ILC1 are rare in healthy liver, but accumulate in cirrhotic livers.

-Unknown #LSEC-derived signals + #TGFβ1 + #il7 drive differentiation of ILC progenitors to ILC1.

-Human #NK cells do not differentiate to ILC1 under multiple conditions ex vivo.

-Human ILC1 make #il2 but functional relevance of this still unknown.

Decoupling #TGFβ1 with phospho-SMAD2 (S457) & phospho-SMAD3 (S423/425) in ascending #AorticAneurysm with #BicuspidAorticValve or #UnicuspidAorticValve

How about TGFβ2/3?

As a comparison, in #TricuspidAorticValve aorta, diameter and elastin break correlate well with increased TGFβ1 level or p-SMAD2/3 levels

Dr. Brittany Balint & Hans-Joachim Schäfers lab, Sci Rep 2022
https://www.nature.com/articles/s41598-022-19335-w