International Conference on Vascular Anomalies: Translating basic research into new therapies (VAC 2025)! :

Exciting program, including novel preclinical models, drugs, and most recent results from clinical trials! lnkd.in/e6_BbzQF. Registrations: lnkd.in/dzTfFVej

#VASCAPA, #HEVAS, #CMTC
#EVBO, #ISSVA #angiogenesis #PIK3CA #TIE2 #KRAS

Laminar #ShearStress reduces plasma leakage and #atheroma formation in atheroprotected regions of the aorta through downstream polarization and endocytosis of VE-PTP and resultant activation of #Tie2. #Atherosclerosis can be suppressed by inhibition of VE-PTP in atheroprone regions that lack VE-PTP sequestration.

By D. McDonald, D. Vestweber & colleagues at MPI for molecular biomedicine & UCSFCancer

🗞️ https://doi.org/10.15252/emmm.202216128