Surprising link found between niacin and risk of heart attack and stroke
https://arstechnica.com/science/2024/02/surprising-link-found-between-niacin-and-risk-of-heart-attack-and-stroke/ #health #diet #cardiovascular #niacin #VitaminB3 #VascularInflammation #metabolomics #supplements

Hearts & minds… also mustn’t forget about those kidneys #CovidPapers #endothelialDamage #VascularInflammation #dementia #alzheimers #CKD

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https://academic.oup.com/ehjcimaging/advance-article-abstract/doi/10.1093/ehjci/jead118/7186983

https://www.nature.com/articles/s44161-023-00336-5

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https://www.biorxiv.org/content/10.1101/2023.09.01.555834v1

#Sirt6 #VascularInflammation

MRTF-A as a deacetylation target of Sirt6 in #EndothelialCell

Deactylated MRTF-A stays in cytoplasm, failing to mediate oxLDL-induced EC ICAM1

An OxLDL-DNMT1 cacade epigenetically silences Sirt6 expression

Dr. Qianyun Wang, Tianfa Li & Qianwen Zhao labs Cell Death Discov 2022
https://www.nature.com/articles/s41420-022-00903-y