You might also enjoy this #neurolecture recalling #hodgkinhuxley #neurohistory seminal quintet of papers, remarking how became aware of their model limitations, written in the 1952 d/4th paper:
Forgotten lesson in nowadays #compneuro models research!
» wetlab interventionist experimentation must remain the principal activity in the search for neurobiological mechanisms, for the same reasons Hodgkin & Huxley realized nearly 70 years ago «
How are seahorses neurons shaped?
How seahorses axons compare to the squids enlarged ones?
HT Your question reminded me of this unique #neurohistory video:
» Over 80 years ago a ground-breaking experiment undertaken at the Laboratory of the Marine Biological Association by Alan #Hodgkin and Andrew #Huxley helped launch a golden era of #neurobiology «
https://youtu.be/g2hysrWbuZs
#JohnBickle #neurohistory lecture:
#compneuro limits
A Hodgkin & A Huxley
1952s
Papers quartet duo written
—with one B Katz trio
Pioneering voltage-clamp squid neural implant.
First action potentials recordings!
Last paper on how maths calculus derived from experiments datasets.
Thus predictions caveat:
Never link causal mechanisms.
ps: Q&A critical feedback:
Skilled lecturer turns into scientific dialogues!
apropos of NMDARs Glutamate:
fav top notch most impressive #scihistory #neurolecture ever!
"Unnoticed Features of Exploratory Experiments from the 60-Year History of the N-methyl - D-aspartate (NMDA) Receptor"
https://youtu.be/xrNrLcE2RZE
John Bickle
2023
From 1949 Hebb
'in one or both cells'
then Watkins, Morris, Collingridge, etc. to
2023 #PhilSci Haueis
#neurophysiology
#neurohistory
#neurodon
#neuroscience
#oldneuropapers
#cogsci
#neurobuzz
#systemsneuroscience
#complexsystems
HT for linking this one!
Recalled that other yours multi lab teams efforts, from which learned tons, specifically because of the open review decision section #1 & #2 ;)
https://elifesciences.org/articles/60824
ps: nowadays phd/book worth effort is awaiting to be written on #neurotech #neurohistory evolution in par with #neurotheory #compneuro maths theorems & formulae employ, disregard, re-employ, & on & so forth.
Something like updated 2007 Nicolelis et al. Methods for Neural Ensemble Recordings.
Ups now reading up to part 1... you already suggested tags 3 days ago or so!
Yet adding generic tags always help in here... then perhaps:
add some tags —even easily by editing after posting— to improve such kind of cool posts, ie:
#neurohistory
#neurodon
#neuroscience
#oldneuropapers
cc
@NicoleCRust for aditional tag suggestions!
@NicoleCRust Sorry, still waiting for the #neurohistory counterpart of Asimov's #psychohistory to take off, to make general predictions about the future behavior of very large neural networks https://en.wikipedia.org/wiki/Psychohistory_(fictional) BTW, Idea 9 is going to be a headache for cortical prosthesis developers, and you have not yet addressed macroscopic effects of quantum entanglement in the brain :-) https://bigthink.com/hard-science/brain-consciousness-quantum-entanglement/
