Lmst

#p97

Issue 14:
Highlight on #ROR1 and #pancreatic #malignancy

Review on viral recognition and #antiviral #interferon response

#Autophagy news from plants and mammals
How #p97 disassembles a regulatory protein complex
Developmental #axon pruning by a #phospholipid #scramblase

Cover: Elisa Nerli, Caren Norden and colleagues

https://www.embopress.org/toc/14602075/2023/42/14

This cover highlights the article Deterministic and probabilistic fate decisions co‐exist in a single retinal lineage by Elisa Nerli, Caren Norden and colleagues. A combination of live imaging and stochastic modelling of single lineage decisions in the zebrafish retina reveals how different neuronal types arise in the correct proportions during development. The cover shows the retina at three days post‐fertilisation, when most neurons are formed and occupy different layers. The different layers are outlined with phalloidin staining in magenta, Muller glial cells are labelled in yellow and retinal ganglion cells in cyan. (Scientific image by the authors)

How does p97/VCP #ATPase achieve selective disassembly of regulatory protein complexes? #CryoEM showing #p97 holding on to one #PP1 partner, while threading another, suggest a hold-and-extract mechanism
Hemmo Meier, Helen Saibil and coworkers
https://www.embopress.org/doi/10.15252/embj.2022113110

Schematic visualization of the article's synopsis

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