Corey_Hopkins

Medicinal chemistry, drug discovery, academia, bicycling, homebrewer, IUChem, PittChem, Professor at University of Nebraska Medical Center

2023-02-13

@PhDMarie This was a great time. I appreciate the chance to talk science and my industry to academia journey.

Corey_Hopkins boosted:
CRAIG M CREWScrews@mstdn.science
2023-01-14
Corey_Hopkins boosted:

RT @aemonten
We are hiring an Assistant Editor for Genes & Development.

Come join me at CSHL.

cshl.peopleadmin.com/postings/

Corey_Hopkins boosted:
CRAIG M CREWScrews@mstdn.science
2022-12-29

nature.com/articles/s41589-022
Nice addition to the #targetedproteindegradation literature but I wouldn't describe it as "a new strategy of targeted protein degradation through direct substrate recruitment to the 26S proteasome" since Janse and Church first described this approach in 2004. pubmed.ncbi.nlm.nih.gov/150394 #PROTACs

2022-12-27

Not a science post per se. Penny Mae on a car ride to help me at the home brew store.

Corey_Hopkins boosted:
2022-12-27

The Arkin Lab at University of California, Berkeley engineered edible microbes (spirulina) to produce acetaminophen (Tylenol). This is an impressive proof-of-concept for "small molecule production derived from CO2, H2O, and light in an edible host for bioavailable, oral drug delivery."

biorxiv.org/content/10.1101/20

from: linkedin.com/in/elliot-hershbe

Corey_Hopkins boosted:
2022-12-27

RT @Shouval
πŸ“’ We are recruiting! The @shouval_lab is looking for bright and motivated researchers interested to join us in our quest to dissect fibroblasts and cancer associated fibroblasts in inflammation and cancer! #Recruiting #CancerResearch

Corey_Hopkins boosted:
2022-12-27

Degrader Review Roundup 3. Concerning all things degradation and the androgen receptor.
sciencedirect.com/science/arti

Corey_Hopkins boosted:
2022-12-24

Hello Mastodonians, I'll be tooting from #Scotland this week.

Corey_Hopkins boosted:
2022-12-24

Our recent work has focused on the development of small-molecule inhibitors for #HDAC enzymes as well as the "undruggable" transcription factors #STAT3 and #STAT5 as potential treatments for hematological malignancies and other cancers.
pubs.acs.org/doi/abs/10.1021/a
nature.com/articles/s41467-019
nature.com/articles/s41375-017

Corey_Hopkins boosted:
2022-12-24

We're a #medicinalchemistry lab in the Centre for Medicinal Chemistry at the University of Toronto Mississauga. Our lab is a dynamic research environment with pharma-quality facilities. Research translation is a central goal of our work, and several companies have sprung out of technologies developed in our lab!
utm.utoronto.ca/cmc/

Corey_Hopkins boosted:
2022-12-24

Check out the work from my colleague Timo Heinrich with on the discovery of MSC-1186 a highly selective SRPK inhibitor identified after fragment screening. pubs.acs.org/doi/10.1021/acs.j
MSC-1186 is also available as probe with the
sgc-ffm.uni-frankfurt.de

Corey_Hopkins boosted:
2022-12-24

πŸ“’ TWO new PhD positions πŸ“’

Join my group in London to work on controllable nucleic acids for biology and medicine! πŸ§¬πŸ”¦πŸŒ‘οΈπŸ”ŠπŸ§«πŸ§ͺ😍

@uclchemistry #chemistry #chemiverse #chemtoots

Application deadline 26th Jan 2023 / Start date Oct 2023

Use the project codes in the below thread to apply through this link - ucl.ac.uk/epsrc-doctoral-train

Get in touch if you have any questions!

Corey_Hopkins boosted:
Fleur M. Fergusonfleur@mstdn.science
2022-12-15

Please share! We are recruiting a #postdoc to work on an exciting #TPD project combining #proteomics and #cancer biology, come join our team! jobrxiv.org/job/university-of-

2022-12-05

Catching up on some C&EN. Devastated to read my friend and mentor Randall Munson has passed. He took me under his wing when I first started at Aventis and learned a ton from him. Both medicinal chemistry and baseball. Spent so many hours talking with him about both as we had offices next door. Kept in touch after leaving for several years and he was always a big supporter of mine as I transitioned to academia. Mentors are difficult to find, but can be lasting.

2022-12-02

Day 1 of my advent calendar.

2022-12-01

What I love about being a PI is the diversity of the students I get to work with. Sometimes that does have challenges due to world issues. One of my talented students, Vika, who is Ukrainian, has been working hard since the Russian invasion to gather medical supplies to send back to Ukraine. It was great to be able to contribute to the cause by getting these awesome pieces of art - one by the great Jeff Koterba.

2022-11-30

First post an a short intro. I’m a medicinal chemist/drug discoverer in academia. My group works on a variety of areas: cancer and neuroscience mainly. For (permanent) fun, when my students discover an in vivo probe, it gets tattooed on me. Can’t wait for our #PROTAC project to be successful, may need my leg.

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