🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.

🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling

AI Breakthrough By UW Scientists Targets ‘Undruggable’ Proteins, Paving Path to Novel Therapies.

#UndruggableNoMore, #AIDrugDiscovery, #PROTAC, #TargetedProteinDegradation, #UWMedicine, #CancerTherapy, #AlzheimersResearch, #MedicalBreakthrough,

https://medium.com/@jckapadia003/ai-breakthrough-by-uw-scientists-targets-undruggable-proteins-paving-path-to-novel-therapies-47b78c5db519

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97619

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97619

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97290

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97290

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97031

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97031

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96653

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96653

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96527

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96527

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96324

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96324

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95939

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95939

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95680

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95680

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95470

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=95470

The July Issue of @CellChemBiol is live! Read it here: https://www.cell.com/cell-chemical-biology/current?utm_source=dlvr.it&utm_medium=mastodon #smoothened #hedgehog #optogenetics #NaVs #Rho-GTPase #YAP1 #MesenchymalStemCells #K2Pchannels #PROTAC #deubiquitylase #chromatin #PARPinhibitors

Targeted protein degradation #PROTAC is a promising avenue for drug development. This study shows that alkenyl oxindole compounds act as novel #E3ligase ligands & recruit the CRL4-DCAF11 E3 #ubiquitin ligase complex for substrate degradation #PLOSBiology https://plos.io/3WV1U9q

#PROTAC from @Novartis team recruiting DCAF1, an E3 ligase essential in cancer, rescues BTK degradation in a cell line that acquired resistance to a CRBN-recruiting PROTAC. Great mechanistic PoC, even though overall effect on cell viability is not as pronounced. https://www.biorxiv.org/content/10.1101/2023.04.09.536153v1

Now online at @Nature Reviews Clinical Oncology from my Arvinas colleague Debbie Chirnomas, myself, and Craig @crews: Protein degraders enter the clinic -- a new approach to cancer therapy. Check it out! #TargetedProteinDegradation #TPD #PROTAC
https://www.nature.com/articles/s41571-023-00736-3

… need to wrangle molecule geometries, etc, to achieve productive ubiquitination by unnatural ligase for TPD therapeutics. And thus less chemistry = quicker development. Great example of ever expanding induced proximity modalities. #TPD #proximity #PROTAC #ubiquitin /end

The lysosomal degraders

#PROTAC +derivatives

An update on Research & Commercialization of #MolecularGlue for targeted protein degradation

"LYTACs, ATACs, AbTACs, KineTACs, PROTABs, AUTACs, ATTECs and AUTOTACs"

Ken Garber Nature Biotech 2022
https://www.nature.com/articles/s41587-022-01594-7

Happy #Heterobifunctional Holidays from the Crewslab! #PROTAC #chemicalbiology #Yale

New patent from
@C4Therapeutics
EGFR DEGRADERS TO TREAT CANCER METASTASIS TO THE BRAIN OR CNS. A lot of CRBN E3 ligand was used in this approach !!! very nice work and impressive results. #PROTAC #EGFR #OSIMERTINIB

First post an a short intro. I’m a medicinal chemist/drug discoverer in academia. My group works on a variety of areas: cancer and neuroscience mainly. For (permanent) fun, when my students discover an in vivo probe, it gets tattooed on me. Can’t wait for our #PROTAC project to be successful, may need my leg.