For #CellMigration lovers
How do cells decide when facing a symmetric junction?
The membrane oscillates exploring both directions until one arm wins.
TLDR: this depends on the actin cytoskeleton & cancer cells decide faster than healthy cells
#scicomm @pj_saez
Full https://www.nature.com/articles/s41567-023-02335-6

For #CellMigration lovers
How do cells decide when facing a symmetric junction?
The membrane oscillates exploring both directions until one arm wins.
TLDR: this depends on the actin cytoskeleton & cancer cells decide faster than healthy cells
#scicomm @pj_saez
Full https://www.nature.com/articles/s41567-023-02335-6

RT @pj_saez
#MayThe4th & #CellMigration

#DarthVader cell using the force to choke another one (arrow/red nucleus) until...well, wait for it to see it in slow motion
Only the sound is missing to be like #StarWars

#scicomm @cellcommlab @focalplane_jcs #MayThe4thBeWithYou #cell

RT @pj_saez
For the long weekend.

#Mitochondria, powerhouse of the #cell were labeled (cyan) and it's possible to visualize how they reach every corner.

All recorded under the microscope by @KuxJohan & @Marie_Adler23 @cellcommlab

#scicomm #microscopy @focalplane_jcs @Mito_News @MitoAging

RT @pj_saez
Last week @Martina_Alamo_R finished her internship @ the @cellcommlab, and left Hamburg.
Now she is back home @LabYuseff 🇨🇱 to finish her #PhD thesis.
Good luck Marti, we already miss you (and your experiments of 300 coverslips 😅 support pic 👇🏼)

RT @pj_saez
#ExSRRF, a new pipeline that allows to reach 25 nm resolution using widefield #microscopy
(useful for #cellbio, #ER_literature, clinics & more)

Tks for the invitation, @PuellesVictor, happy that @cellcommlab we could help you w this neat work

@NatureNano https://www.nature.com/articles/s41565-023-01328-z

Expansion microscopy + SRFF = #ExSRFF
low cost super resolution microscopy
https://www.nature.com/articles/s41565-023-01328-z

RT @robinsall
A short thread about Adam Dowdell's excellent chemotaxis paper, just out in @CurrentBiology. It shows how combinations of ligands for the same receptors cause fascinating & counterintuitive outcomes (1/n)
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00294-4

RT @pj_saez
Hot from the press @CurrentBiology

Competition between chemoattractants causes unexpected complexity and can explain negative chemotaxis, by A Dowdell, et al @robinsall lab.

Great story for #CellMigration lovers

Full: https://www.cell.com/current-biology/fulltext/S0960-9822(23)00294-4 #scicomm

Here we are again accumulating celebrations
@cellcommlab
Kudos to @Marie_Adler23 for finishing your MSc !
All the hard work paid out and you got a beautiful thesis.

#SciWin #CellMigration #WomenInStem

RT @CellMigration
Coming tuesday 14th at 11 am ET, we will have two wonderful speakers Prof. Gina Razidlo on lipid storage during tumor cell migration and Dr. Raghavan Thiagarajan on pulsation and flows!

Don't forget to tune in on zoom or YouTube https://youtube.com/@cellmigrationseminars4300

RT @pj_saez
#CellMigration for house cleaning!

Immune cell (i.e. #DendriticCell), moves to remove 2 death cells (arrows)

This is what happens in our body when normal tissue cells die, they are scanned & removed by leukocytes (also macrophages)

#scicomm @cellcommlab @focalplane_jcs #nomoa

#CellMigration for house cleaning!

Immune cell (i.e. #DendriticCell), moves to remove 2 death cells (arrows)

This is pretty much what happens in our body when normal tissue cells die, they are scanned & removed by leukocytes (also macrophages)

#scicomm @cellcommlab @focalplane

Beautiful #EM view of the #organelles by @Marie_Adler23 @cellcommlab
Look at those #mitochondria !!

(Excellent display by the panning macro of @christlet)
@Mito_News #scicomm #electromicroscopy #microscopy #scichat #science #nomoa

RT @pj_saez
At this point of aging you actually start to get emotional, & the @cellcommlab is pushing hard in that direction.
Look the surprise they had for me today! 😍

Chocolate cake was👌🏼. The wine joke is 😂, they know my sense of humour. The match of hair colour on the card is also 😂

Thanks @mariana_deniz @focalplane_jcs, it was super fun talking to you & refresh nice memories of my labs.
It was also a nice chance to somehow thank and acknowledge so many friends, colleagues and collaborators that have shaped my scientific path. (There are many more though...)
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RT @mariana_deniz
In our @focalplane_jcs series of interviews to #LatinAmerican🔬today we have 🇨🇱 @pj_saez , professor at @cellcommlab 🇩🇪 @UKEHamburg sin…
https://twitter.com/mariana_deniz/status/1615331196195508224

This is why we love #CellMigration !!
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RT @jytinevez
It also allow for the detection of divisions.
It was built to harness this kind of movies:
https://twitter.com/jytinevez/status/1615756706826391553

RT @mariana_deniz
In our @focalplane_jcs series of interviews to #LatinAmerican🔬today we have 🇨🇱 @pj_saez , professor at @cellcommlab 🇩🇪 @UKEHamburg since 2020. He tells us about his inspiration with microscopy following amoeba in water as a young student,... https://focalplane.biologists.com/2023/01/17/an-interview-with-pablo-j-saez/

RT @pj_saez
Interesting paper @NaturePhotonics:
"Artificial confocal #microscopy for deep label-free imaging"

Of note, last author Gabriel Popescu passed last year.

(CC @christlet @HenriquesLab @DrAnneCarpenter)
https://www.nature.com/articles/s41566-022-01140-6 #scicomm @EuroBioImaging @NEUBIAS_COST @BioImagingUK

Let's start 2023 with a #FluorescenceFriday !

Busy intracellular life videoed under a microscope.

Actin cystokeleton providing scaffold (cyan), membrane dancing non-stop (grey), and membranous organelles reaching every corner (orange).

#scicomm @cellcommlab @focalplane_jcs