#ProteinEngineering #TRPChannels #SyntheticBiology #VisionRestoration #Retina #GeneTherapy

Work by Morgan Chevalier, Firas Fadel, Tímea Májer , Daniel Magda, Ferenc Kilin, Lili Gerendas and in collaboration with the labs of Zoltan Z Nagy, Szabo Arnold, and
Botond Roska.

tl;dr: We trimmed human TRPV1 so it wakes up at ~41°C. Brief near‑IR “warm‑pulses” made ganglion cells in blind human retina explants fire graded spikes—no opsins, no nanoparticles, just AAV + human protein. Early‑stage, clean thermal control.
https://www.sciencedirect.com/science/article/pii/S016777992500318X

Just published: Engineering infrared light detection in blind human retina using ultrasensitive human TRPV1 channels.

Pavlov

Highly collectable!

Hello Mastodon, , our first preprint on vision restoration is online:
https://www.biorxiv.org/content/10.1101/2025.01.08.631889v1

Here is a schematic representation of a Fourier-transform infrared (FTIR) spectrometer (ChatGPT 4o)

@th Engelbewaarder?

@North beautiful stuff!

@North I was sure this Blender! Fusion 360, really?

@th what happened to your website? Your public lab notebook was an inspiration

@neauoire

not exactly same style, but interesting/fun:

- creative banter[https://podcasts.apple.com/us/podcast/creative-banter/id1625143379]
- oxide and friends[https://oxide.computer/podcasts/oxide-and-friends]
- pick, place podcast[https://www.pickplacepodcast.com/]

Going back to roots

@th How does one get a static IP in the Netherlands?

And the sun does rise in Amsterdam.

The sun rises in Amsterdam

Turns out human dendrites are less excitable after all,
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01675-8

Hello World!