🛠️ Is it possible to rewire cellular energy control by targeting a single protein domain?

🔗 Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.12.007

📚 CSBJ: https://www.csbj.org/

#Mitochondria #CellBiology #CalciumSignaling #ProteinEngineering #ProteinScience #StructuralBiology #Bioenergetics #MolecularDynamics #Biophysics #MCU #MCUb #NMR

🐍 Ah, the age-old problem of snake bites, now to be solved by a few protein design tools. Because why not replace centuries of biological evolution with a couple of lines of code? 🖥️😂 Spoiler: 5,000 words later, we're no closer to a solution, but at least it's a fun read on the way to the ER. 🚑🤷‍♂️
https://www.owlposting.com/p/will-protein-design-tools-solve-the #snakebites #proteinengineering #technology #humor #healthcare #HackerNews #ngated

🚀 What role does protein design play in advancing next-gen optogenetic tools?

🔗 Protein design accelerates the development and application of optogenetic tools. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.014

📚 CSBJ: https://www.csbj.org/

#Optogenetics #ProteinEngineering #Neuroscience #AlphaFold #ProteinDesign #SyntheticBiology

🔬 New Review Published!
Explore the exciting world of enzymatic protein fusion—where we combine enzymes to enhance biological activity and precision. From biocatalysis to gene therapy and biosensing, fusion proteins are reshaping biotech innovation.
🧬 Read the full article: https://doi.org/10.1016/j.cis.2025.103473

#FusionProteins #ProteinEngineering #EnzymeTechnology #SyntheticBiology #Biocatalysis #GeneTherapy #Biosensing #Bioengineering #Biotechnology #MolecularBiology #NextGenBiotech #ScienceMastodon

This study introduces plmCP, an innovative method for detecting circular permutations (CPs) in proteins using Protein Language Models (PLMs)—paving the way for deeper insights into protein evolution, engineering, and synthetic biology.

🔗 Detection of circular permutations by Protein Language Models. Computational and Structural Biotech Journal, DOI: https://doi.org/10.1016/j.csbj.2024.12.029

📚 CSBJ: https://www.csbj.org/

#ProteinScience #AIinBiotech #SyntheticBiology #Bioinformatics #ProteinEngineering

New AI can design proteins in minutes, a process that would normally take millions of years! 🤯

Find the full article at this link https://codelabsacademy.com/news/simulating-evolution-how-esm3-language-model-transforms-protein-development-2024-22-5?source=mastodon

#artificialintelligence #proteinengineering

An intriguing talk by Prof. Amiram (BGU) on using unnatural amino acids to design proteins with specific melting temps and self-assembly properties, alterable by light. Her work on photocrosslinkable polypeptides enables creation of thermoresponsive nano/micro-gels. Exciting advances in #proteinengineering and #syntheticbiology.

If you've ever done a bit of #ProteinEngineering or #DirectedEvolution you know that funny things can happen 🤯 – and sometimes it's worth following up!

I'm excited to share that our paper is finally out in Nature Chemistry! 🎉

Read it here:
https://www.nature.com/articles/s41557-024-01490-4

Autonomous platform engineers enhanced proteins

By Fernando Gomollón-Bel @gomobel
25 January 2024

https://www.chemistryworld.com/news/autonomous-platform-engineers-enhanced-proteins/4018841.article

#ChemiVerse #ProteinScience #ProteinEngineering #SyntheticBiology

Loren Looger, legendary protein wrangler, who always generously shared their genetically encoded calcium indicators and more while still in development and unpublished, is asking for labs to co-write grants with him:

"Dear science world, I need help, please. If you like the tools and data we generate, and our shareware attitude, can you please co-apply for funding with us? It turns out that I'm terrible at writing grants, and we need $$ or else we can't make more GCaMPs, RCaMPs, SnFRs (we've branched out to neuromodulators and neuropeptides), FPs, viruses, tags, etc. We'll also make whatever you want, but we need $$ to do it. DM or email me, sooner is better. Sorry to be desperate, but we want to keep doing this, and I'm not sure we can."

https://profiles.ucsd.edu/loren.looger

#neuroscience #GCaMP #RCaMP #SnFR #ProteinEngineering #GECIs

New calcium sensor WHaloCaMP from Helen Farrants and Eric Schreiter, can be used with many different colored dyes -- check out the awesome videos of it in action here: https://twitter.com/HelenFarrants/status/1681994810205384704?s=20

Paper here: https://www.biorxiv.org/content/10.1101/2023.07.18.549527v1
#neuroscience #proteins #janelia #proteinengineering #zebrafish

Redoing my expression testing today. I think I’m going to get more consistent results from this one. Hopefully I’ll have something interesting to say for group meeting this week. #chemistry #biochemistry #proteinengineering #proteins

Pretty comprehensive #biocatalysis effort for large yields of L-ABA! Optimizing plasmids, #proteinengineering, and crystal structures, what more could you want? doi.org/10.1002/cbic.202300148

Også en #Introduktion på dansk #NyPåMastodon

Professionelt har jeg lavet #Strukturbiologi og privat har jeg brugt meget tid på at spille klarinet og #musik mest #klassisk og #jazz

Jeg læser bøger når jeg kan, både #fantasy og #scifi, senest også #clifi, klimafiktion.
Vokset op med #StarTrek TNG, men kan også lide #StarWars

Jeg går meget op i #bæredygtighed og håber på at #ProteinEngineering og #Enzymer kan være med til at skubbe det i den rigtige retning.

Sønderjyde bosat i Storkøbenhavn

#Introduction #Introduktion

I've spent a lot of my life doing #StructuralBiology and playing #Music #ClassicalMusic.

I like to #read #books, mostly #fantasy but also #clifi and #scifi.
A fan of both #StarTrek and #StarWars, each has its merits. (Yes TNG is the best, but only because I grew up with it).

Currently I'm interested in #biosustainability #sustainability, #enzymology and #ProteinEngineering. I think those technologies are important for our future together.

Danish 🇩🇰

Gänseblumen, Erbsen, Raps & Co.: Forscher:innen der #UniHohenheim in #Stuttgart wollen #Gluten-#Protein im Brot durch neue Alternativ-Proteine ersetzen. Zucht & #ProteinEngineering könnten Ergebnisse noch verbessern.

Im neuen #ScienceSnack Video gibt Doktorandin Natalie Feller einen Einblick in ihre Forschung an der kleinsten Backstraße der Welt.

Zur Pressemitteilung: http://ow.ly/9C0f50OvcOn
Zum Video: https://www.youtube.com/watch?v=K8ERozxFAns

#HohenheimProtein #ProteinForschung #Gesundheit #zoliakie

📌 Breaking News! 🌟 Magnoreach has shared a must-read article on how AI-Driven Systems Create Custom Proteins with Precision. 🧬💻

Explore the cutting-edge field of artificial intelligence in protein engineering. Don't miss this fascinating read! Read it here: https://bit.ly/3Wq0qSh

#AI #ProteinEngineering #Magnoreach

`The resulting ‘jGCaMP8’ sensors, based on the calcium-binding protein calmodulin and a fragment of endothelial nitric oxide synthase, have ultra-fast kinetics (half-rise times of 2 ms) and the highest sensitivity for neural activity reported for a protein-based calcium sensor. jGCaMP8 sensors will allow tracking of large populations of neurons on timescales relevant to neural computation.`

https://www.nature.com/articles/s41586-023-05828-9

#proteinEngineering #calciumIons #kinetics #neuroscience #neuroimaging #sensing

The era of #proteindesign really is coming along nicely.

#proteinengineering
#enzymeengineering

https://www.nature.com/articles/s41586-023-05696-3

Twitter thread from Institute for Protein Design
https://twitter.com/UWproteindesign/status/1628438074404507648?t=goy2swbeDBU7nux-nmG9jg&s=19