#ProteinEngineering #TRPChannels #SyntheticBiology #VisionRestoration #Retina #GeneTherapy
#TRPChannels
Blissful ignorance is a vibe.
But so is coughing up phlegm for 20 minutes after a “clean” hit.
If you’d rather not know what’s cooking in your cart, skip this post.
If you’re curious? You might not unsee it.
🔗 https://doctorapprovedcannabis.substack.com/p/why-cannabis-makes-you-cough-and?r=58khz
#VaporScience #TRPChannels #CannabisMedicine #DoctorKnowsBest
Study offers a potential pathway for safer, non-addictive pain management
"The study showed that when D₂O passed through the TRPV1 channel, it suppressed pain signal transmission and achieved effective analgesia."
They studied both human cells in vitro and mice. This is good since another study found that D2O activated sweet taste receptors in humans, but not in mice -
Sweet taste of heavy water
https://www.nature.com/articles/s42003-021-01964-y
#HeavyWater #D2O #solvents #TRPchannels #SweetTasteReceptors #Pain
#nociception #TRPV1 #neuroscience #biology #MouseVsHuman
"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."
https://doi.org/10.1177/0960327119877460
#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology
research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
https://doi.org/10.1016/j.bbadis.2015.12.014
Getting on to the faculty job market this season - scary and exciting!
My background is in: #TRPChannels and #GPCRsignaling pathways,
#ionchannel gating mechanisms,
mouse, Drosophila and mosquito #sensorybiology and #behavior
with an early training in physics and a stint in electrical engineering with an automobile manufacturing company :).
Here to share stories on this academic life, research, technical tips and tricks.
Very excited to learn new things from you all!
Today's reading topic to distract/entertain/self-soothe -
Would messing with ankyrin mess up both Piezo and TRP channel function? What would be the implications for immune function?
articles to read:
Human ankyrins and their contribution to disease biology: An update
https://www.ias.ac.in/article/fulltext/jbsc/045/0146
Actin dynamics as critical ion channel regulator: ENaC and Piezo in focus
https://doi.org/10.1152/ajpcell.00368.2020
Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822220/
Roles of TRP and PIEZO receptors in autoimmune diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11140548/
okay, that should be enough
also an hour of body scan meditation
& some Perilla tea
#TRPchannels #Piezo #ENaC #ankyrin #autoimmunity #ImmuneSystem
Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine (2017)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490394/
#TRPchannels #TRPM8 #Pain #Migraine #ChronicPain #nocicieption
Have my MPhil viva next Monday in deepest darkest Cambridge! Reading up on TRP channels, naked mole-rats, cloning and apoptosis. Here is a beautiful review on the role of TRP channels in pain.
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