Interesting paper this - sounds like much more to come on the microbiome effects of ibezapolstat - effects look significant vs those of vancomycin. Will be interesting to see if in any way this accelerates recovery of C diff colitis and prevention of recurrence #IDSky #ClinMicro #MicroSky

RE: https://bsky.app/profile/did:plc:yhddktxw22k3ylm2zzzwlbqt/post/3lrfh63gzfc2k

Great schematic reminder of different antifungals' coverage! #IDSky #ClinMicro

RE: https://bsky.app/profile/did:plc:waxmnur6pk6xy55nwbzofjwj/post/3lrdm6fxdpk2v

Not per se a clinical trial but evidence points towards source control (surgery) being key in brain abscesses. #IDSky #ClinMicro #AMR @cidjournal.bsky.social academic.oup.com/cid/advance-...

Non-Operative versus Neurosurg...

🔽 antibiotic sales for livestock 👉 🔽 antibiotic resistance in livestock. Livestock = an important, *modifiable* reservoir of #AMR #IDSky #ClinMicro @bsacandjac.bsky.social

Decreasing antimicrobial resis...

If interested, this is the primary paper for this BBC news article #IDSky #ClinMicro #AMR (2/2) www.journalofinfection.com/article/S016...

Faecal microbiota transplant t...

Poo pills - perhaps not the alluring treatment name, but gets the message across! #IDSky #ClinMIcro #AMR (1/2)

Doctors use poo pills to flush...

Useful reminder, especially as SGLT2 inhibitors only going to become more and more common. #IDSky #ClinMicro #UTISky

RE: https://bsky.app/profile/did:plc:au5lnpbox3s3pbyihkeiqjzk/post/3lqqc3i4g6s23

Important finding. Widespread antibiotic use, with best intentions, has long term #AMR consequences. "Azithromycin MDA is associated with macrolide resistance that persists and potentially spreads to untreated populations." #IDSky #ClinMicro #MedSky @thelancetinfdis.bsky.social

Long-term effects of azithromy...

Really informative episode for my morning commute today! Includes: - ALABAMA - safety & impact of penicillin delabelling - EAGLE-1 - gepotidacin for gonorrhoea - SOLARIO - shortening Abx for ortho infections - another trial on fosfo stepdown for UTI #IDSky #ClinMicro #UTISky @cmicomms.bsky.social

RE: https://bsky.app/profile/did:plc:ao7ykaoap23gbmrggv4ytobn/post/3lqlb6cdpdr2g

So long. Probably too long. #IDSky #ClinMicro #AMR

RE: https://bsky.app/profile/did:plc:6peijvvlgjki2rrxitoa65sv/post/3lpwegcf4we2j

Reaching consensus definitions on diseases is hard. Exemplified here by complicated urinary tract infections in @thelancetinfdis.bsky.social Important implications: - how to test new antibiotics? - is current definition correct? #IDSky #ClinMicro #AMR #UTISky www.thelancet.com/journals/lan...

Consensus position statement o...

Did not know this was a thing (even if rare) Tigecycline-induced hypoglycaemia #IDSky #ClinMicro #AMR @jac-amr.bsky.social academic.oup.com/jacamr/artic...

Incidence, characteristics and...

This is helpful, opening up a new drug (tigecycline) to be put into elastomeric devices for patients that need #OPAT #IDSky #ClinMicro #AMR @jac-amr.bsky.social academic.oup.com/jac...

Cefepime–Taniborbactam - another long antibiotic combination name to learn (& to spell)! #IDSky #ClinMicro #AMR (1/3)

Cefepime-Taniborbactam—a Novel...

Phages as treatment for infections are coming. Lots of steps to get right first though. @cmijournal.bsky.social #IDSky #ClinMicro www.clinicalmicrobiologyandinfection.com/article/S119...

Phages and phage-borne enzymes...

Challenges and opportunities of using antibiotic combinations to tackle antibiotic resistance. @natmicrobiol.nature.com #AMR #IDSky #ClinMicro #UTISky www.nature.com/articles/s41...

Combining antibiotics to tackl...

Nope, nitrites alone no good as an indication for needing antibiotics for a UTI. (i.e. can be positive in asymptomatic bacteriuria) #IDSky #UTISky #ClinMicro academic.oup.com/ajcp/article...

Urinary Nitrite and Urinary-tr...

Quick bit of CPD for a Sunday morning. Had not appreciated association between this infection & coffee... #IDSky #ClinMicro @cidjournal.bsky.social academic.oup.com/cid/advance-...

Too Much Coffee: A Rare Cause ...

Excellent summary #AMR diagram 👇 #IDSky #ClinMicro

RE: https://bsky.app/profile/did:plc:obzmodhumpztnas3eumpknln/post/3lnnao3zuwc2x

The benefit of azithromycin to prevent hospital re-admission in Kenyan children may be stratified by presence of azithromycin resistance genes #IDSky #ClinMicro #AMR academic.oup.com/jid/advance-...

Impact of macrolide resistance...