K63 #Ubiquitination of #YAP by SKP2 #E3Ligase⏫its nuclear import🤠

Synergized with mTORC1-PERK-ATF4 axis in renal #Cystogenesis🐭#JuvenileCysticKidney #Ciliopathy

A #CellCycle-specific regulation of YAP?😆

Dr. Andrew Karaplis lab JCI 2022
https://www.jci.org/articles/view/153943