On the limits of 16S rRNA gene-based metagenome prediction and functional profiling

"16S rRNA gene-based functional inference tools generally do not have the necessary sensitivity to delineate health-related functional changes in the microbiome and should thus be used with care"

https://www.biorxiv.org/content/10.1101/2023.11.07.564315v1

#metabarcoding #16S #rRNA #CopyNumber #bias #FunctionalInference #prediction